6'-(4-methylpiperazin-1-yl)-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-2,3'-bipyridine

Base Information

Chemical Name:6'-(4-methylpiperazin-1-yl)-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-2,3'-bipyridine
CAS No.:1333492-70-8
Molecular Formula:C₄₂H₃₇N₇
Molecular Weight:639.803
Hs Code.:

Synonyms:6'-(4-methylpiperazin-1-yl)-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-2,3'-bipyridine

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Chemical Property of 6'-(4-methylpiperazin-1-yl)-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-2,3'-bipyridine

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Technology Process of 6'-(4-methylpiperazin-1-yl)-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-2,3'-bipyridine

There total 6 articles about 6'-(4-methylpiperazin-1-yl)-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-2,3'-bipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 446880-83-7
2-bromo-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)pyridine

: 918524-63-7
1-methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine

: 1333492-70-8
6'-(4-methylpiperazin-1-yl)-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-2,3'-bipyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; at 140 ℃; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.bmcl.2010.12.120

Reference yield:

: (E)-2-(2-Bromo-pyridin-4-yl)-3-dimethylamino-1-pyridin-2-yl-propenone

: 1333492-70-8
6'-(4-methylpiperazin-1-yl)-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-2,3'-bipyridine

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / N,N-dimethyl-formamide / 24 h / 20 - 50 °C / Inert atmosphere

2: triethylamine / dichloromethane

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 140 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 3: Suzuki-Miyaura coupling;
DOI:10.1016/j.bmcl.2010.12.120

Reference yield:

: 4926-28-7
2-Bromo-4-picoline

: 1333492-70-8
6'-(4-methylpiperazin-1-yl)-4-(3-(pyridin-2-yl)-1-trityl-1H-pyrazol-4-yl)-2,3'-bipyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.5 h / -50 °C / Inert atmosphere

1.2: -50 - 45 °C / Inert atmosphere

2.1: acetic acid / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

2.2: 1.5 h / Inert atmosphere

3.1: hydrazine hydrate / N,N-dimethyl-formamide / 24 h / 20 - 50 °C / Inert atmosphere

4.1: triethylamine / dichloromethane

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; toluene / 140 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium hexamethylsilazane; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 5.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.bmcl.2010.12.120