Technology Process of N-(2,6-dichlorophenyl)-5-ethyl-3-(methylthio)-1,2,4-triazine-6-carboxamide
There total 6 articles about N-(2,6-dichlorophenyl)-5-ethyl-3-(methylthio)-1,2,4-triazine-6-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-ethyl-3-(methylthio)-1,2,4-triazine-6-carboxylic acid;
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 5 - 20 ℃;
for 2h;
2,6-Dichloroaniline;
With
pyridine;
In
dichloromethane;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuryl dichloride / dichloromethane / 4 h / 20 °C
2.1: triethylamine / N,N-dimethyl-formamide / Cooling with ice
2.2: 20 h / 20 °C
3.1: sulfuryl dichloride / dichloromethane / 16 h / 20 °C / Cooling with ice
4.1: sodium hydrogencarbonate / ethanol / 4 h / Reflux
5.1: lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C
6.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 5 - 20 °C
6.2: 16 h / 20 °C
With
sulfuryl dichloride; oxalyl dichloride; sodium hydrogencarbonate; triethylamine; N,N-dimethyl-formamide; lithium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / N,N-dimethyl-formamide / Cooling with ice
1.2: 20 h / 20 °C
2.1: sulfuryl dichloride / dichloromethane / 16 h / 20 °C / Cooling with ice
3.1: sodium hydrogencarbonate / ethanol / 4 h / Reflux
4.1: lithium hydroxide / tetrahydrofuran; methanol / 1 h / 20 °C
5.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 5 - 20 °C
5.2: 16 h / 20 °C
With
sulfuryl dichloride; oxalyl dichloride; sodium hydrogencarbonate; triethylamine; N,N-dimethyl-formamide; lithium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
