(R,Z)-3-((2-bromo-5-fluorophenyl)(hydroxy)methyl)-4-phenylbut-3-en-2-one

Base Information

Chemical Name:(R,Z)-3-((2-bromo-5-fluorophenyl)(hydroxy)methyl)-4-phenylbut-3-en-2-one
CAS No.:1208074-45-6
Molecular Formula:C₁₇H₁₄BrFO₂
Molecular Weight:349.199
Hs Code.:

Synonyms:(R,Z)-3-((2-bromo-5-fluorophenyl)(hydroxy)methyl)-4-phenylbut-3-en-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,Z)-3-((2-bromo-5-fluorophenyl)(hydroxy)methyl)-4-phenylbut-3-en-2-one

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Technology Process of (R,Z)-3-((2-bromo-5-fluorophenyl)(hydroxy)methyl)-4-phenylbut-3-en-2-one

There total 1 articles about (R,Z)-3-((2-bromo-5-fluorophenyl)(hydroxy)methyl)-4-phenylbut-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1030919-27-7
C₁₃H₁₈OSi

: 94569-84-3
2-bromo-5-fluorobenzaldehyde

: 1208074-45-6
(R,Z)-3-((2-bromo-5-fluorophenyl)(hydroxy)methyl)-4-phenylbut-3-en-2-one

Guidance literature:: C₁₃H₁₈OSi; 2-bromo-5-fluorobenzaldehyde; With (R,R)-N,N-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexanediaminochromium(III) hexafluoroantimonate; 2,6-di-tert-butyl-4-methylpyridine; In dichloromethane; at -30 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 0.25h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ja909669e

Reference yield: 78.0%

: 1208074-45-6
(R,Z)-3-((2-bromo-5-fluorophenyl)(hydroxy)methyl)-4-phenylbut-3-en-2-one

: 1208074-63-8
C₁₇H₁₃FO₂

Guidance literature:: With 1,2,2,6,6-pentamethylpiperidine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 150 ℃; optical yield given as %ee; Microwave irradiation; Inert atmosphere;
DOI:10.1021/ja909669e