5-(4-benzyloxy-3-methoxyphenyl)-5-ethylbarbituric acid

Base Information

• Chemical Name: 5-(4-benzyloxy-3-methoxyphenyl)-5-ethylbarbituric acid
• CAS No.: 110879-28-2
• Molecular Formula: C₂₀H₂₀N₂O₅
• Molecular Weight: 368.389
• Mol file: 110879-28-2.mol

Synonyms:5-(4-benzyloxy-3-methoxyphenyl)-5-ethylbarbituric acid

Chemical Property of 5-(4-benzyloxy-3-methoxyphenyl)-5-ethylbarbituric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-benzyloxy-3-methoxyphenyl)-5-ethylbarbituric acid

There total 6 articles about 5-(4-benzyloxy-3-methoxyphenyl)-5-ethylbarbituric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.2%

urea (57-13-6) + diethyl 4-benzyloxy-3-methoxyphenylethylmalonate (110879-29-3) → 5-(4-benzyloxy-3-methoxyphenyl)-5-ethylbarbituric acid (110879-28-2)

Guidance literature:

With potassium tert-butylate; In dimethylsulfoxide-d6; Ambient temperature;

DOI:10.1002/jps.2600760617

Reference yield:

methyl 4-benzyloxy-3-methoxyphenylethanoate (16209-54-4) → 5-(4-benzyloxy-3-methoxyphenyl)-5-ethylbarbituric acid (110879-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / sodium / 1 h / Heating

2: 1.) NaH / 1) DMF; 2) DMF, 25 deg C, 16 h

3: 27.2 percent / potassium t-butoxide / dimethylsulfoxide-d6 / Ambient temperature

With potassium tert-butylate; sodium; sodium hydride; In dimethylsulfoxide-d6;

DOI:10.1002/jps.2600760617

Reference yield:

4-carbethoxy-3-methoxyphenylethanoic acid (110879-32-8) → 5-(4-benzyloxy-3-methoxyphenyl)-5-ethylbarbituric acid (110879-28-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 85 percent / diethyl ether / 0.5 h / Ambient temperature

2: 65 percent / potassium carbonate / methanol / 20 h / Heating

3: 82 percent / sodium / 1 h / Heating

4: 1.) NaH / 1) DMF; 2) DMF, 25 deg C, 16 h

5: 27.2 percent / potassium t-butoxide / dimethylsulfoxide-d6 / Ambient temperature

With potassium tert-butylate; sodium; sodium hydride; potassium carbonate; In methanol; dimethylsulfoxide-d6; diethyl ether;

DOI:10.1002/jps.2600760617

upstream raw materials:

urea

diethyl 4-benzyloxy-3-methoxyphenylethylmalonate

methyl 4-benzyloxy-3-methoxyphenylethanoate

4-carbethoxy-3-methoxyphenylethanoic acid

Downstream raw materials:

5-(4-benzyloxy-3-methoxyphenyl)-1,5-diethylbarbituric acid

5-(4-benzyloxy-3-methoxyphenyl)-1,3,5-triethylbarbituric acid