(R,R)-4-<4'-(hydroxymethyl)phenyl>-5-<3',5'-bis(benzyloxy)phenyl>-2,2-dimethyl-1,3-dioxolane

Base Information

Chemical Name:(R,R)-4-<4'-(hydroxymethyl)phenyl>-5-<3',5'-bis(benzyloxy)phenyl>-2,2-dimethyl-1,3-dioxolane
CAS No.:202578-87-8
Molecular Formula:C₃₂H₃₂O₅
Molecular Weight:496.603
Hs Code.:

Synonyms:(R,R)-4-<4'-(hydroxymethyl)phenyl>-5-<3',5'-bis(benzyloxy)phenyl>-2,2-dimethyl-1,3-dioxolane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,R)-4-<4'-(hydroxymethyl)phenyl>-5-<3',5'-bis(benzyloxy)phenyl>-2,2-dimethyl-1,3-dioxolane

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Technology Process of (R,R)-4-<4'-(hydroxymethyl)phenyl>-5-<3',5'-bis(benzyloxy)phenyl>-2,2-dimethyl-1,3-dioxolane

There total 9 articles about (R,R)-4-<4'-(hydroxymethyl)phenyl>-5-<3',5'-bis(benzyloxy)phenyl>-2,2-dimethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 4-[(4R,5R)-5-(3,5-Bis-benzyloxy-phenyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-benzoic acid methyl ester

: 202578-87-8
(R,R)-4-<4'-(hydroxymethyl)phenyl>-5-<3',5'-bis(benzyloxy)phenyl>-2,2-dimethyl-1,3-dioxolane

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 1h;
DOI:10.1021/jo961587w

Reference yield:

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: 202578-87-8
(R,R)-4-<4'-(hydroxymethyl)phenyl>-5-<3',5'-bis(benzyloxy)phenyl>-2,2-dimethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1: 24 h / 120 °C

2: 1.) NaH, 2.) K₃Fe(CN)6, K₂CO₃, K₂2(OH)4>, (DHQD)2PHAL, methanesulfonamide, 3.) p-TsOH*H₂O / 1.) THF, room temperature, 36 h, 2.) t-BuOH, H₂O, toluene, 0 deg C, 48 , 3.) DMF, reflux, 2 h

3: 97 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

With lithium aluminium tetrahydride; methanesulfonamide; K2; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III); In diethyl ether;
DOI:10.1021/jo961587w

Reference yield:

: 14295-52-4
4-(diethyoxyphosphorylmethyl)benzoic acid methyl ester

: 202578-87-8
(R,R)-4-<4'-(hydroxymethyl)phenyl>-5-<3',5'-bis(benzyloxy)phenyl>-2,2-dimethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH, 2.) K₃Fe(CN)6, K₂CO₃, K₂2(OH)4>, (DHQD)2PHAL, methanesulfonamide, 3.) p-TsOH*H₂O / 1.) THF, room temperature, 36 h, 2.) t-BuOH, H₂O, toluene, 0 deg C, 48 , 3.) DMF, reflux, 2 h

2: 97 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

With lithium aluminium tetrahydride; methanesulfonamide; K2; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III); In diethyl ether;
DOI:10.1021/jo961587w