1-[3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methyl-1-oxopropyl] L-proline 1,1-dimethylethyl ester

Base Information

Chemical Name:1-[3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methyl-1-oxopropyl] L-proline 1,1-dimethylethyl ester
CAS No.:444106-76-7
Molecular Formula:C₃₂H₄₆N₂O₄Si
Molecular Weight:550.814
Hs Code.:

Synonyms:1-[3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methyl-1-oxopropyl] L-proline 1,1-dimethylethyl ester

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Chemical Property of 1-[3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methyl-1-oxopropyl] L-proline 1,1-dimethylethyl ester

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Technology Process of 1-[3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methyl-1-oxopropyl] L-proline 1,1-dimethylethyl ester

There total 2 articles about 1-[3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methyl-1-oxopropyl] L-proline 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 2812-46-6
proline tert-butyl ester

: 443982-37-4
3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methylpropionic acid

: 444106-76-7
1-[3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methyl-1-oxopropyl] L-proline 1,1-dimethylethyl ester

Guidance literature:: 3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methylpropionic acid; With benzotriazol-1-ol; dacarbazine; In dichloromethane; at 0 ℃; for 0.0833333h;

proline tert-butyl ester; In dichloromethane; at 0 - 20 ℃; for 12h; Further stages.;
DOI:10.1021/ja026158w

Reference yield:

: 202743-49-5
3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]propionic acid

: 444106-76-7
1-[3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methyl-1-oxopropyl] L-proline 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1 h / 0 °C

1.2: 71 percent / tetrahydrofuran; hexane / 2.5 h / -78 °C

2.1: DIC; HOBt / CH₂Cl₂ / 0.08 h / 0 °C

2.2: 58 percent / CH₂Cl₂ / 12 h / 0 - 20 °C

With benzotriazol-1-ol; dacarbazine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja026158w