3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methylpropionic acid

Base Information

• Chemical Name: 3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methylpropionic acid
• CAS No.: 443982-37-4
• Molecular Formula: C₂₃H₃₁NO₃Si
• Molecular Weight: 397.59
• Mol file: 443982-37-4.mol

Synonyms:3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methylpropionic acid

Chemical Property of 3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methylpropionic acid

There total 1 articles about 3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]propionic acid (202743-49-5) + methyl iodide (74-88-4) → 3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methylpropionic acid (443982-37-4)

Guidance literature:

3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]propionic acid; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at 0 ℃; for 1h;

methyl iodide; In tetrahydrofuran; hexane; at -78 ℃; for 2.5h; Further stages.;

DOI:10.1021/ja026158w

Reference yield: 58.0%

proline tert-butyl ester (2812-46-6) + 3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methylpropionic acid (443982-37-4) → 1-[3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methyl-1-oxopropyl] L-proline 1,1-dimethylethyl ester (444106-76-7)

Guidance literature:

3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methylpropionic acid; With benzotriazol-1-ol; dacarbazine; In dichloromethane; at 0 ℃; for 0.0833333h;

proline tert-butyl ester; In dichloromethane; at 0 - 20 ℃; for 12h; Further stages.;

DOI:10.1021/ja026158w

Reference yield:

3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methylpropionic acid (443982-37-4) → (S)-1-{3-[(1-Benzoylamino-3-methyl-butyl)-hydroxy-methyl-silanyl]-2-methyl-propionyl}-pyrrolidine-2-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1.1: DIC; HOBt / CH₂Cl₂ / 0.08 h / 0 °C

1.2: 58 percent / CH₂Cl₂ / 12 h / 0 - 20 °C

2.1: 46 percent / CF₃SO₃H / CH₂Cl₂ / 0.42 h / 0 °C

With trifluorormethanesulfonic acid; benzotriazol-1-ol; dacarbazine; In dichloromethane;

DOI:10.1021/ja026158w

upstream raw materials:

3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]propionic acid

methyl iodide

Downstream raw materials:

1-[3-[[1-(benzoylamino)-3-methylbutyl]methylphenylsilyl]-2-methyl-1-oxopropyl] L-proline 1,1-dimethylethyl ester