4-[[1-[[3-(1,1-dimethylethyl)phenyl]sulfonyl]-3-methyl-5-(trifluoro-methyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]benzoic acid

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Chemical Name:4-[[1-[[3-(1,1-dimethylethyl)phenyl]sulfonyl]-3-methyl-5-(trifluoro-methyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]benzoic acid
CAS No.:1314841-91-2
Molecular Formula:C₂₇H₂₅F₃N₂O₄S
Molecular Weight:530.568
Hs Code.:

Synonyms:4-[[1-[[3-(1,1-dimethylethyl)phenyl]sulfonyl]-3-methyl-5-(trifluoro-methyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]benzoic acid

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Chemical Property of 4-[[1-[[3-(1,1-dimethylethyl)phenyl]sulfonyl]-3-methyl-5-(trifluoro-methyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]benzoic acid

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Technology Process of 4-[[1-[[3-(1,1-dimethylethyl)phenyl]sulfonyl]-3-methyl-5-(trifluoro-methyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]benzoic acid

There total 4 articles about 4-[[1-[[3-(1,1-dimethylethyl)phenyl]sulfonyl]-3-methyl-5-(trifluoro-methyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1314841-92-3
2-bromomethyl-1-(3-(1,1-dimethylethyl)phenylsulfonyl)-3-methyl-5-trifluoromethyl-1H-pyrrolo[3,2-b]pyridine

: 14047-29-1
4-carboxyphenylboronic acid

: 1314841-91-2
4-[[1-[[3-(1,1-dimethylethyl)phenyl]sulfonyl]-3-methyl-5-(trifluoro-methyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]benzoic acid

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In Dimethyl ether; water; for 2h; Reflux;

Reference yield:

: 920979-04-0
2-iodo-6-(trifluoromethyl)pyridin-3-amine

: 1314841-91-2
4-[[1-[[3-(1,1-dimethylethyl)phenyl]sulfonyl]-3-methyl-5-(trifluoro-methyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 20 °C

1.2: 1 h / Reflux

2.1: potassium carbonate; lithium chloride / palladium diacetate / N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 48 h / Reflux

4.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / Dimethyl ether; water / 2 h / Reflux

With pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; caesium carbonate; lithium chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; In tetrachloromethane; Dimethyl ether; water; N,N-dimethyl-formamide;

Reference yield:

: 1314186-71-4
3-(1,1-dimethylethyl)-N-(2-iodo-6-trifluoromethylpyridin-3-yl)benzenesulfonamide

: 1314841-91-2
4-[[1-[[3-(1,1-dimethylethyl)phenyl]sulfonyl]-3-methyl-5-(trifluoro-methyl)-1H-pyrrolo[3,2-b]pyridin-2-yl]methyl]benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; lithium chloride / palladium diacetate / N,N-dimethyl-formamide / 0.5 h / 100 °C / Microwave irradiation

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 48 h / Reflux

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / Dimethyl ether; water / 2 h / Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; caesium carbonate; lithium chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; In tetrachloromethane; Dimethyl ether; water; N,N-dimethyl-formamide;