2,3-dihydro-4-chloroacetyl-6-phenyl-5-methylpyrazino<3,2,1-hi>indole

Base Information

• Chemical Name: 2,3-dihydro-4-chloroacetyl-6-phenyl-5-methylpyrazino<3,2,1-hi>indole
• CAS No.: 89450-97-5
• Molecular Formula: C₁₉H₁₇ClN₂O
• Molecular Weight: 324.81
• Mol file: 89450-97-5.mol

Synonyms:2,3-dihydro-4-chloroacetyl-6-phenyl-5-methylpyrazino<3,2,1-hi>indole

Chemical Property of 2,3-dihydro-4-chloroacetyl-6-phenyl-5-methylpyrazino<3,2,1-hi>indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dihydro-4-chloroacetyl-6-phenyl-5-methylpyrazino<3,2,1-hi>indole

There total 2 articles about 2,3-dihydro-4-chloroacetyl-6-phenyl-5-methylpyrazino<3,2,1-hi>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2,3-dihydro-6-phenyl-5-methylpyrazino<3,2,1-hi>indole (89450-96-4) + chloroacetyl chloride (79-04-9) → 2,3-dihydro-4-chloroacetyl-6-phenyl-5-methylpyrazino<3,2,1-hi>indole (89450-97-5)

Guidance literature:

DOI:10.1007/BF00842847

Reference yield:

2,3-dihydro-2-oxo-6-phenyl-5-methylpyrazino<3,2,1-hi>indole (53374-86-0) → 2,3-dihydro-4-chloroacetyl-6-phenyl-5-methylpyrazino<3,2,1-hi>indole (89450-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / NaBH₄ / acetic acid; dioxane

2: 80 percent

With sodium tetrahydroborate; In 1,4-dioxane; acetic acid;

DOI:10.1007/BF00842847

Reference yield: 15.0%

2,3-dihydro-4-chloroacetyl-6-phenyl-5-methylpyrazino<3,2,1-hi>indole (89450-97-5) → 4,5,7,8-tetrahydro-7-oxo-1-phenyl-2-methylpyrrolo<1,2-a:2',1'-c>quinoxaline (89450-98-6)

Guidance literature:

With aluminium trichloride; In neat (no solvent); at 130 - 170 ℃; for 3h;

DOI:10.1007/BF00842847

upstream raw materials:

2,3-dihydro-6-phenyl-5-methylpyrazino<3,2,1-hi>indole

chloroacetyl chloride

2,3-dihydro-2-oxo-6-phenyl-5-methylpyrazino<3,2,1-hi>indole

Downstream raw materials:

4,5,7,8-tetrahydro-7-oxo-1-phenyl-2-methylpyrrolo<1,2-a:2',1'-c>quinoxaline