2-(4-Fluorophenyl)-6-[(R)-3-methylpiperazin-1-yl]-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine

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Chemical Name:2-(4-Fluorophenyl)-6-[(R)-3-methylpiperazin-1-yl]-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine
CAS No.:1228216-91-8
Molecular Formula:C₂₄H₂₂FN₇
Molecular Weight:427.484
Hs Code.:

Synonyms:2-(4-Fluorophenyl)-6-[(R)-3-methylpiperazin-1-yl]-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine

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Chemical Property of 2-(4-Fluorophenyl)-6-[(R)-3-methylpiperazin-1-yl]-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine

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Technology Process of 2-(4-Fluorophenyl)-6-[(R)-3-methylpiperazin-1-yl]-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine

There total 4 articles about 2-(4-Fluorophenyl)-6-[(R)-3-methylpiperazin-1-yl]-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228217-23-9
2-(4-fluorophenyl)-6-[(3R)-3-methylpiperazin-1-yl]-3-{1-[(4-methylphenyl)sulphonyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}imidazo[1,2-b]pyridazine

: 1228216-91-8
2-(4-Fluorophenyl)-6-[(R)-3-methylpiperazin-1-yl]-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine

Guidance literature:: With water; sodium hydroxide; In methanol; at 60 ℃; for 0.5h;

Reference yield:

: 1095708-39-6
6-chloro-2-(4-fluorophenyl)-3-iodoimidazo[1,2-b]pyridazine

: 1228216-91-8
2-(4-Fluorophenyl)-6-[(R)-3-methylpiperazin-1-yl]-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 18 h / Inert atmosphere; Reflux

2: triethylamine / pentan-1-ol / 24 h / Reflux

3: sodium hydroxide; water / methanol / 0.5 h / 60 °C

With water; caesium carbonate; triethylamine; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; pentan-1-ol; water;

Reference yield:

: 244081-70-7
6-Chloro-2-(4-fluorophenyl)imidazo[1,2-b]pyridazine

: 1228216-91-8
2-(4-Fluorophenyl)-6-[(R)-3-methylpiperazin-1-yl]-3-(1H-pyrrolo[2,3-b]pyridin-4-yl)imidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1: Iodine monochloride / chloroform / 4 h / 0 - 20 °C

2: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; tetrahydrofuran / 18 h / Inert atmosphere; Reflux

3: triethylamine / pentan-1-ol / 24 h / Reflux

4: sodium hydroxide; water / methanol / 0.5 h / 60 °C

With water; Iodine monochloride; caesium carbonate; triethylamine; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; pentan-1-ol; chloroform; water;