(R)-2-[(4S,5S,6S)-6-((S)-1-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-4-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-butan-1-ol

Base Information

• Chemical Name: (R)-2-[(4S,5S,6S)-6-((S)-1-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-4-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-butan-1-ol
• CAS No.: 182572-04-9
• Molecular Formula: C₄₉H₇₈O₁₁
• Molecular Weight: 843.152
• Mol file: 182572-04-9.mol

Synonyms:(R)-2-[(4S,5S,6S)-6-((S)-1-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-4-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-butan-1-ol

Chemical Property of (R)-2-[(4S,5S,6S)-6-((S)-1-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-4-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-[(4S,5S,6S)-6-((S)-1-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-4-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-butan-1-ol

There total 8 articles about (R)-2-[(4S,5S,6S)-6-((S)-1-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-4-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C50H78O12 (182571-82-0) → (R)-2-[(4S,5S,6S)-6-((S)-1-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-4-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-butan-1-ol (182572-04-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; 0 deg C to RT;

DOI:10.1016/0040-4039(96)01504-3

Reference yield:

(R)-4-Isopropyl-3-[4-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-butyryl]-oxazolidin-2-one → (R)-2-[(4S,5S,6S)-6-((S)-1-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-4-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-butan-1-ol (182572-04-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 70 percent / (TMS)2NLi / tetrahydrofuran / -50 °C

2: LiOH, H₂O₂ / tetrahydrofuran; H₂O / 0 °C

3: benzene; methanol / Ambient temperature

4: TBAF / tetrahydrofuran / Ambient temperature

5: CSA / CH₂Cl₂ / Ambient temperature

6: 100 percent / CSA / CH₂Cl₂ / Ambient temperature

7: 90 percent / LiAlH₄ / diethyl ether / 0 deg C to RT

With lithium hydroxide; lithium aluminium tetrahydride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; dihydrogen peroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; benzene;

DOI:10.1016/0040-4039(96)01504-3

Reference yield:

(2S,3R,4R,5R,6R)-6-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3,5-dihydroxy-2-[2-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-ethyl]-4-methyl-heptanoic acid methyl ester → (R)-2-[(4S,5S,6S)-6-((S)-1-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-4-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-butan-1-ol (182572-04-9)

Guidance literature:

Multi-step reaction with 3 steps

1: CSA / CH₂Cl₂ / Ambient temperature

2: 100 percent / CSA / CH₂Cl₂ / Ambient temperature

3: 90 percent / LiAlH₄ / diethyl ether / 0 deg C to RT

With lithium aluminium tetrahydride; camphor-10-sulfonic acid; In diethyl ether; dichloromethane;

DOI:10.1016/0040-4039(96)01504-3

upstream raw materials:

C₅₀H₇₈O₁₂

(2R,3S,4S)-4-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-pentanal

C₅₈H₉₅NO₁₃Si

Downstream raw materials:

C₅₄H₈₁NO₁₀S

(3S,5S,6R)-5-Methoxy-3-(4-methoxy-benzyloxy)-6-[(4S,6R)-6-((S)-1-{(4S,5S,6S)-6-[(S)-3-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-1-methyl-propyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-heptan-1-ol

C₄₅H₇₄O₁₁