(3S,5S,6R)-5-Methoxy-3-(4-methoxy-benzyloxy)-6-[(4S,6R)-6-((S)-1-{(4S,5S,6S)-6-[(S)-3-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-1-methyl-propyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-heptan-1-ol

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Chemical Name:(3S,5S,6R)-5-Methoxy-3-(4-methoxy-benzyloxy)-6-[(4S,6R)-6-((S)-1-{(4S,5S,6S)-6-[(S)-3-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-1-methyl-propyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-heptan-1-ol
CAS No.:182571-88-6
Molecular Formula:C₄₂H₇₂O₁₀
Molecular Weight:737.028
Hs Code.:

(3S,5S,6R)-5-Methoxy-3-(4-methoxy-benzyloxy)-6-[(4S,6R)-6-((S)-1-{(4S,5S,6S)-6-[(S)-3-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-1-methyl-propyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-heptan-1-ol

Synonyms:(3S,5S,6R)-5-Methoxy-3-(4-methoxy-benzyloxy)-6-[(4S,6R)-6-((S)-1-{(4S,5S,6S)-6-[(S)-3-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-1-methyl-propyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-heptan-1-ol

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Chemical Property of (3S,5S,6R)-5-Methoxy-3-(4-methoxy-benzyloxy)-6-[(4S,6R)-6-((S)-1-{(4S,5S,6S)-6-[(S)-3-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-1-methyl-propyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-heptan-1-ol

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Technology Process of (3S,5S,6R)-5-Methoxy-3-(4-methoxy-benzyloxy)-6-[(4S,6R)-6-((S)-1-{(4S,5S,6S)-6-[(S)-3-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-1-methyl-propyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-heptan-1-ol

There total 7 articles about (3S,5S,6R)-5-Methoxy-3-(4-methoxy-benzyloxy)-6-[(4S,6R)-6-((S)-1-{(4S,5S,6S)-6-[(S)-3-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-1-methyl-propyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-heptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 182571-86-4
C₅₄H₈₁NO₁₀S

: 182571-88-6
(3S,5S,6R)-5-Methoxy-3-(4-methoxy-benzyloxy)-6-[(4S,6R)-6-((S)-1-{(4S,5S,6S)-6-[(S)-3-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-1-methyl-propyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-heptan-1-ol

Guidance literature:: With hydrogen; nickel; In ethanol; Ambient temperature;
DOI:10.1016/0040-4039(96)01504-3

Reference yield:

: 182571-79-5
(2R,3S,4S)-4-{(4R,6S)-6-[(1R,2S,4S)-6-Benzyloxy-2-methoxy-4-(4-methoxy-benzyloxy)-1-methyl-hexyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-3-(tert-butyl-dimethyl-silanyloxy)-2-methyl-pentanal

: 182571-88-6
(3S,5S,6R)-5-Methoxy-3-(4-methoxy-benzyloxy)-6-[(4S,6R)-6-((S)-1-{(4S,5S,6S)-6-[(S)-3-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-1-methyl-propyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-heptan-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1: 70 percent / (TMS)2NLi / tetrahydrofuran / -50 °C

2: LiOH, H₂O₂ / tetrahydrofuran; H₂O / 0 °C

3: benzene; methanol / Ambient temperature

4: TBAF / tetrahydrofuran / Ambient temperature

5: CSA / CH₂Cl₂ / Ambient temperature

6: 100 percent / CSA / CH₂Cl₂ / Ambient temperature

7: 90 percent / LiAlH₄ / diethyl ether / 0 deg C to RT

8: 95 percent / n-Bu₃P, pyridine / Ambient temperature

9: 93 percent / H₂ / Raney - Ni / ethanol / Ambient temperature

With pyridine; lithium hydroxide; lithium aluminium tetrahydride; tributylphosphine; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; lithium hexamethyldisilazane; nickel; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; benzene;
DOI:10.1016/0040-4039(96)01504-3

Reference yield:

: C₅₃H₈₈O₁₂Si

: 182571-88-6
(3S,5S,6R)-5-Methoxy-3-(4-methoxy-benzyloxy)-6-[(4S,6R)-6-((S)-1-{(4S,5S,6S)-6-[(S)-3-((2S,4R,6S)-4-methoxy-6-methyl-tetrahydro-pyran-2-yl)-1-methyl-propyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-heptan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: TBAF / tetrahydrofuran / Ambient temperature

2: CSA / CH₂Cl₂ / Ambient temperature

3: 100 percent / CSA / CH₂Cl₂ / Ambient temperature

4: 90 percent / LiAlH₄ / diethyl ether / 0 deg C to RT

5: 95 percent / n-Bu₃P, pyridine / Ambient temperature

6: 93 percent / H₂ / Raney - Ni / ethanol / Ambient temperature

With pyridine; lithium aluminium tetrahydride; tributylphosphine; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; nickel; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane;
DOI:10.1016/0040-4039(96)01504-3