[1-(2-Amino-ethyl)-6-chloro-1H-indol-3-yl]-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

Base Information

Chemical Name:[1-(2-Amino-ethyl)-6-chloro-1H-indol-3-yl]-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone
CAS No.:923296-74-6
Molecular Formula:C₂₁H₂₂ClFN₄O
Molecular Weight:400.883
Hs Code.:

Synonyms:[1-(2-Amino-ethyl)-6-chloro-1H-indol-3-yl]-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

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Chemical Property of [1-(2-Amino-ethyl)-6-chloro-1H-indol-3-yl]-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

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Technology Process of [1-(2-Amino-ethyl)-6-chloro-1H-indol-3-yl]-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

There total 2 articles about [1-(2-Amino-ethyl)-6-chloro-1H-indol-3-yl]-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 459817-82-4
2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester

: (6-chloro-1H-indol-3-yl)-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

: 923296-74-6
[1-(2-Amino-ethyl)-6-chloro-1H-indol-3-yl]-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

Guidance literature:: (6-chloro-1H-indol-3-yl)-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With hydrogenchloride; water; sodium hydrogencarbonate; more than 3 stages; Product distribution / selectivity;

Reference yield:

: (6-chloro-1H-indol-3-yl)-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

: 689-98-5
chloroethylamine

: 923296-74-6
[1-(2-Amino-ethyl)-6-chloro-1H-indol-3-yl]-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone

Guidance literature:: (6-chloro-1H-indol-3-yl)-[4-(2-fluoro-phenyl)-piperazin-1-yl]-methanone; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

chloroethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 14h; Product distribution / selectivity;