4-Amino-5-chloro-2-fluorophenol

Base Information

• Chemical Name: 4-Amino-5-chloro-2-fluorophenol
• CAS No.: 847872-10-0
• Molecular Formula: C₆H₅ClFNO
• Molecular Weight: 161.563
• European Community (EC) Number: 860-983-4
• DSSTox Substance ID: DTXSID001303722
• Mol file: 847872-10-0.mol

Synonyms:4-Amino-5-chloro-2-fluorophenol;847872-10-0;4-amino-5-chloro-2-fluoro-phenol;Phenol, 4-amino-5-chloro-2-fluoro-;Phenol, 4-amino-5-chloro-2-fluoro-;SCHEMBL4843454;GAICBADMNLLFDV-UHFFFAOYSA-N;DTXSID001303722;AMY28068;MFCD16877887;AKOS027417493;SB75790;DS-18830;CS-0098764;C76703;EN300-366591;Z1255500950

Chemical Property of 4-Amino-5-chloro-2-fluorophenol

Chemical Property:

• PSA: 46.25000
• LogP: 2.34810
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 161.0043696
• Heavy Atom Count: 10
• Complexity: 124

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-5-chloro-2-fluorophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=CC(=C1F)O)Cl)N

Technology Process of 4-Amino-5-chloro-2-fluorophenol

There total 4 articles about 4-Amino-5-chloro-2-fluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.3%

potassium 5-chloro-2-fluoro-4-nitrophenolate → 4-amino-5-chloro-2-fluoro-phenol (847872-10-0)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 20 ℃; for 10h;

Reference yield:

5-chloro-2-fluoro-4-nitrophenol → 4-amino-5-chloro-2-fluoro-phenol (847872-10-0)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 25 ℃; for 2h; Inert atmosphere;

Reference yield:

2-chloro-4,5-difluoronitrobenzene (771-76-6) → 4-amino-5-chloro-2-fluoro-phenol (847872-10-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; water / 3 h / Reflux

2: iron; ammonium chloride / ethanol; water / 10 h / 20 °C

With water; iron; ammonium chloride; potassium hydroxide; In ethanol; water;

upstream raw materials:

2-chloro-4,5-difluoronitrobenzene

4-chloro-1,2-difluorobenzene