771-76-6

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4,5-difluoronitrobenzene is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for substitution, reduction, or coupling reactions, enabling the creation of a wide range of medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-4,5-difluoronitrobenzene serves as an essential precursor for the development of pesticides and other crop protection agents. Its reactivity facilitates the production of effective and targeted agrochemicals.
Due to the potential toxicity and environmental impact of 2-Chloro-4,5-difluoronitrobenzene, strict adherence to proper handling and disposal procedures is crucial when working with 2-CHLORO-4,5-DIFLUORONITROBENZENE in any application.

Upstream product

• 696-02-6 4-chloro-1,2-difluorobenzene 

Downstream Products

• 2613-32-3 2-chloro-4,5-difluoroaniline 
• 949559-51-7 1-(4-methoxybenzyl)-4-(5-chloro-2-fluoro-4-nitrophenoxy)-3-iodo-1H-pyrazolo[3,4-b]pyridine 
• 677741-97-8 1-chloro-4-fluoro-5-methoxy-2-nitrobenzene 
• 1093221-99-8 di(tert-butyl) (5-chloro-2-fluoro-4-nitrophenyl)malonate 
• 677741-98-9 2-chloro-5-fluoro-4-methoxyaniline 
• 1552281-02-3 4-(5-chloro-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide 
• 847872-10-0 4-amino-5-chloro-2-fluoro-phenol 
• 212694-66-1 2-chloro-5-fluoro4-piperazinonitrobenzene 
• 212914-52-8 2-chloro4-diethylamino-5-fluoronitrobenzene 
• 2267-98-3 6-chloro-3,4-difluorophenol 

Relevant academic research and scientific papers

SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

SUBSTITUTED QUINOLINE COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted quinoline compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

IMIDAZO [1,2A] PYRIDINE DERIVATIVES, THEIR USE AS S1P1 AGONISTS AND METHODS FOR THEIR PRODUCTION

The invention is directed to Compounds of Formula (I) as well as methods of making and using the compounds.

Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist

Optimization of benzoic acid derivatives by introducing substituents into the diphenyl urea moiety led to the identification of compound 20l as a potent VLA-4 antagonist. Compound 20l inhibited eosinophil infiltration into bronchial alveolar lavage fluid

Heterobicyclic pyrazole compounds and methods of use

Compounds of Formulas Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting receptor tyrosine kinases and for treating disorders mediated thereby. Methods of using compounds of Formula Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

PYRIDINO AND PYRIMIDINO PYRAZINONES FOR TREATMENT OF ANXIETY AND DEPRESSION

The present invention provides compounds of Formula (I): wherein the variables A, B, Ar, R1, R2, and R3 are as defined herein. The compounds of Formula (I) can function as corticotropin releasing factor (CRF) receptor anta