2-chloro-N-(4-methyl-2-oxochromen-7-yl)benzamide

Base Information

• Chemical Name: 2-chloro-N-(4-methyl-2-oxochromen-7-yl)benzamide
• CAS No.: 847795-49-7
• Molecular Formula: C₁₇H₁₂ClNO₃
• Molecular Weight: 313.74
• ChEMBL ID: CHEMBL1311920
• DSSTox Substance ID: DTXSID601324487
• Mol file: 847795-49-7.mol

Synonyms:2-chloro-N-(4-methyl-2-oxochromen-7-yl)benzamide;MLS001171602;CHEMBL1311920;DTXSID601324487;HMS2895D16;AKOS034107745;WAY-653157;847795-49-7;SMR000591896;SR-01000071117;SR-01000071117-1;Z29731141

Chemical Property of 2-chloro-N-(4-methyl-2-oxochromen-7-yl)benzamide

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 313.0505709
• Heavy Atom Count: 22
• Complexity: 490

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C3=CC=CC=C3Cl

Technology Process of 2-chloro-N-(4-methyl-2-oxochromen-7-yl)benzamide

There total 1 articles about 2-chloro-N-(4-methyl-2-oxochromen-7-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.5%

7-amino-4-methylcoumarin. (26093-31-2) + o-chlorobenzoyl chloride (609-65-4) → 2-chloro-N-(4-methyl-2-oxo-2H-chromen-7-yl)benzamide (847795-49-7)

Guidance literature:

With pyridine; In acetone; at 20 ℃;

Reference yield:

2-chloro-N-(4-methyl-2-oxo-2H-chromen-7-yl)benzamide (847795-49-7) + methyl iodide (74-88-4) → C18H14ClNO3

Guidance literature:

2-chloro-N-(4-methyl-2-oxo-2H-chromen-7-yl)benzamide; With sodium hydride; In hexane; N,N-dimethyl-formamide; for 0.333333h;

methyl iodide; In hexane; N,N-dimethyl-formamide; for 5h;

DOI:10.3390/ijms21155584

upstream raw materials:

7-amino-4-methylcoumarin.

o-chlorobenzoyl chloride