(S)-3-((R)-2-{(2R,3S,5R,6S)-6-[((S)-2-Acetylamino-3-phenyl-propionylamino)-methyl]-3-benzyloxycarbonylmethoxy-5-isobutoxy-tetrahydro-pyran-2-yl}-propionylamino)-N-((S)-1-benzyloxycarbonyl-2-phenyl-ethyl)-succinamic acid benzyl ester

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Chemical Name:(S)-3-((R)-2-{(2R,3S,5R,6S)-6-[((S)-2-Acetylamino-3-phenyl-propionylamino)-methyl]-3-benzyloxycarbonylmethoxy-5-isobutoxy-tetrahydro-pyran-2-yl}-propionylamino)-N-((S)-1-benzyloxycarbonyl-2-phenyl-ethyl)-succinamic acid benzyl ester
CAS No.:259726-54-0
Molecular Formula:C₆₀H₇₀N₄O₁₃
Molecular Weight:1055.23
Hs Code.:

(S)-3-((R)-2-{(2R,3S,5R,6S)-6-[((S)-2-Acetylamino-3-phenyl-propionylamino)-methyl]-3-benzyloxycarbonylmethoxy-5-isobutoxy-tetrahydro-pyran-2-yl}-propionylamino)-N-((S)-1-benzyloxycarbonyl-2-phenyl-ethyl)-succinamic acid benzyl ester

Synonyms:(S)-3-((R)-2-{(2R,3S,5R,6S)-6-[((S)-2-Acetylamino-3-phenyl-propionylamino)-methyl]-3-benzyloxycarbonylmethoxy-5-isobutoxy-tetrahydro-pyran-2-yl}-propionylamino)-N-((S)-1-benzyloxycarbonyl-2-phenyl-ethyl)-succinamic acid benzyl ester

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Chemical Property of (S)-3-((R)-2-{(2R,3S,5R,6S)-6-[((S)-2-Acetylamino-3-phenyl-propionylamino)-methyl]-3-benzyloxycarbonylmethoxy-5-isobutoxy-tetrahydro-pyran-2-yl}-propionylamino)-N-((S)-1-benzyloxycarbonyl-2-phenyl-ethyl)-succinamic acid benzyl ester

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Technology Process of (S)-3-((R)-2-{(2R,3S,5R,6S)-6-[((S)-2-Acetylamino-3-phenyl-propionylamino)-methyl]-3-benzyloxycarbonylmethoxy-5-isobutoxy-tetrahydro-pyran-2-yl}-propionylamino)-N-((S)-1-benzyloxycarbonyl-2-phenyl-ethyl)-succinamic acid benzyl ester

There total 7 articles about (S)-3-((R)-2-{(2R,3S,5R,6S)-6-[((S)-2-Acetylamino-3-phenyl-propionylamino)-methyl]-3-benzyloxycarbonylmethoxy-5-isobutoxy-tetrahydro-pyran-2-yl}-propionylamino)-N-((S)-1-benzyloxycarbonyl-2-phenyl-ethyl)-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 2018-61-3
(S)-2-acetylamino-3-phenylpropanoic acid

: (S)-3-[(R)-2-((2R,3S,5R,6S)-6-Aminomethyl-3-benzyloxycarbonylmethoxy-5-isobutoxy-tetrahydro-pyran-2-yl)-propionylamino]-N-((S)-1-benzyloxycarbonyl-2-phenyl-ethyl)-succinamic acid benzyl ester

: 259726-54-0
(S)-3-((R)-2-{(2R,3S,5R,6S)-6-[((S)-2-Acetylamino-3-phenyl-propionylamino)-methyl]-3-benzyloxycarbonylmethoxy-5-isobutoxy-tetrahydro-pyran-2-yl}-propionylamino)-N-((S)-1-benzyloxycarbonyl-2-phenyl-ethyl)-succinamic acid benzyl ester

Guidance literature:: With TEA; diethyl dicarbonate; In tetrahydrofuran;
DOI:10.1016/S0960-894X(98)00575-7

Reference yield:

: 100-39-0
benzyl bromide

: 259726-54-0
(S)-3-((R)-2-{(2R,3S,5R,6S)-6-[((S)-2-Acetylamino-3-phenyl-propionylamino)-methyl]-3-benzyloxycarbonylmethoxy-5-isobutoxy-tetrahydro-pyran-2-yl}-propionylamino)-N-((S)-1-benzyloxycarbonyl-2-phenyl-ethyl)-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃

2: TFA, anisole

3: TEA

4: 88 percent / DEPC, TEA / tetrahydrofuran

5: TFA, anisole

6: 85 percent / DEPC, TEA / tetrahydrofuran

With TEA; potassium carbonate; methoxybenzene; diethyl dicarbonate; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1016/S0960-894X(98)00575-7

Reference yield:

: 259726-52-8
(R)-2-((2R,3S,5R,6S)-6-Aminomethyl-3-benzyloxycarbonylmethoxy-5-isobutoxy-tetrahydro-pyran-2-yl)-propionic acid

: 259726-54-0
(S)-3-((R)-2-{(2R,3S,5R,6S)-6-[((S)-2-Acetylamino-3-phenyl-propionylamino)-methyl]-3-benzyloxycarbonylmethoxy-5-isobutoxy-tetrahydro-pyran-2-yl}-propionylamino)-N-((S)-1-benzyloxycarbonyl-2-phenyl-ethyl)-succinamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: TEA

2: 88 percent / DEPC, TEA / tetrahydrofuran

3: TFA, anisole

4: 85 percent / DEPC, TEA / tetrahydrofuran

With TEA; methoxybenzene; diethyl dicarbonate; trifluoroacetic acid; In tetrahydrofuran;
DOI:10.1016/S0960-894X(98)00575-7