(E)-4-[(1R,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-but-3-en-2-one

Base Information

Chemical Name:(E)-4-[(1R,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-but-3-en-2-one
CAS No.:121843-00-3
Molecular Formula:C₁₈H₃₄O₃Si
Molecular Weight:326.552
Hs Code.:

Synonyms:(E)-4-[(1R,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-but-3-en-2-one

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Chemical Property of (E)-4-[(1R,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-but-3-en-2-one

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Technology Process of (E)-4-[(1R,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-but-3-en-2-one

There total 6 articles about (E)-4-[(1R,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-but-3-en-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 121843-00-3
(E)-4-[(1R,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-but-3-en-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / (i-Pr)2NEt / CH₂Cl₂ / Ambient temperature

2: 91 percent / LiAlH₄ / tetrahydrofuran / 0 °C

3: 94 percent / pyridinium chlorochromate, molecular sieves / CH₂Cl₂ / Ambient temperature

4: 2.) 2N HCl / 1.) Et₂O, -45 deg C -> r.t.; 2.) Et₂O, 0 deg C

With hydrogenchloride; lithium aluminium tetrahydride; molecular sieve; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.19880710505

Reference yield:

: 121842-98-6
(2S,4aS,5S,8aS)-2-(tert-butyl)perhydro-4a,5-dimethyl-2H,4H-<1,3>benzodioxin-4-one

: 121843-00-3
(E)-4-[(1R,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-but-3-en-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / LiOH / tetrahydrofuran; methanol; H₂O / Ambient temperature

2: 99 percent / diethyl ether / 0 °C

3: 98 percent / (i-Pr)2NEt / CH₂Cl₂ / Ambient temperature

4: 91 percent / LiAlH₄ / tetrahydrofuran / 0 °C

5: 94 percent / pyridinium chlorochromate, molecular sieves / CH₂Cl₂ / Ambient temperature

6: 2.) 2N HCl / 1.) Et₂O, -45 deg C -> r.t.; 2.) Et₂O, 0 deg C

With hydrogenchloride; lithium hydroxide; lithium aluminium tetrahydride; molecular sieve; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water;
DOI:10.1002/hlca.19880710505

Reference yield:

: 121772-22-3
[(1R,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-methanol

: 121843-00-3
(E)-4-[(1R,2S,6S)-1,2-Dimethyl-6-(2-trimethylsilanyl-ethoxymethoxy)-cyclohexyl]-but-3-en-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / pyridinium chlorochromate, molecular sieves / CH₂Cl₂ / Ambient temperature

2: 2.) 2N HCl / 1.) Et₂O, -45 deg C -> r.t.; 2.) Et₂O, 0 deg C

With hydrogenchloride; molecular sieve; pyridinium chlorochromate; In dichloromethane;
DOI:10.1002/hlca.19880710505