Technology Process of methanesulfonic acid 2-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenoxy]ethyl ester
There total 7 articles about methanesulfonic acid 2-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenoxy]ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetic acid; hydrazine hydrate / ethanol / 0.25 h / 140 °C / Microwave irradiation
1.2: 160 °C
2.1: trifluoroacetic acid / 1,4-dioxane / 20 °C
3.1: potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0) / water; 1,4-dioxane / 1 h / 100 °C / Inert atmosphere
4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 20 °C
4.2: 16 h / 20 °C
5.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C
6.1: triethylamine / 2 h / 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); lithium aluminium tetrahydride; sodium hydride; hydrazine hydrate; acetic acid; triethylamine; trifluoroacetic acid; potassium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water; mineral oil;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium 2-methylbutan-2-olate / tetrahydrofuran; toluene / 20 °C
1.2: 0.33 h / 20 °C
2.1: hydrazine hydrate / ethanol / 0.25 h / 140 °C / Microwave irradiation
3.1: trifluoroacetic acid / 1,4-dioxane / 20 °C
4.1: potassium hydroxide; tris-(dibenzylideneacetone)dipalladium(0) / water; 1,4-dioxane / 1 h / 100 °C / Inert atmosphere
5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 20 °C
5.2: 16 h / 20 °C
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C
7.1: triethylamine / 2 h / 20 °C
With
tris-(dibenzylideneacetone)dipalladium(0); lithium aluminium tetrahydride; sodium hydride; potassium 2-methylbutan-2-olate; hydrazine hydrate; triethylamine; trifluoroacetic acid; potassium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene; mineral oil;
![2-[4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)phenoxy]ethanol](/Databaselist/images/loading.webp)
