(R)-((2R,S-4S)-2-hydroxy-4-((R)-8-(4-methoxybenzyloxy)-7-methyl-1-oxoisochroman-3-yl)pentyl) 2-methylpent-4-ynoate

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Chemical Name:(R)-((2R,S-4S)-2-hydroxy-4-((R)-8-(4-methoxybenzyloxy)-7-methyl-1-oxoisochroman-3-yl)pentyl) 2-methylpent-4-ynoate
CAS No.:1278519-69-9
Molecular Formula:C₂₉H₃₄O₇
Molecular Weight:494.585
Hs Code.:

Synonyms:(R)-((2R,S-4S)-2-hydroxy-4-((R)-8-(4-methoxybenzyloxy)-7-methyl-1-oxoisochroman-3-yl)pentyl) 2-methylpent-4-ynoate

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Chemical Property of (R)-((2R,S-4S)-2-hydroxy-4-((R)-8-(4-methoxybenzyloxy)-7-methyl-1-oxoisochroman-3-yl)pentyl) 2-methylpent-4-ynoate

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Technology Process of (R)-((2R,S-4S)-2-hydroxy-4-((R)-8-(4-methoxybenzyloxy)-7-methyl-1-oxoisochroman-3-yl)pentyl) 2-methylpent-4-ynoate

There total 10 articles about (R)-((2R,S-4S)-2-hydroxy-4-((R)-8-(4-methoxybenzyloxy)-7-methyl-1-oxoisochroman-3-yl)pentyl) 2-methylpent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 134773-04-9
(2R)-2-methylpent-4-yonic acid

: 1278519-68-8
(R)-3-((2R,S-4S)-1,2-dihydroxypentan-4-yl)-8-(4-methoxybenzyloxy)-7-methylisochroman-1-one

: 1278519-69-9
(R)-((2R,S-4S)-2-hydroxy-4-((R)-8-(4-methoxybenzyloxy)-7-methyl-1-oxoisochroman-3-yl)pentyl) 2-methylpent-4-ynoate

Guidance literature:: With dmap; diisopropyl-carbodiimide; In dichloromethane; at -40 - 20 ℃; for 0.5h;
DOI:10.1021/ol200331u

Reference yield:

: 1278519-64-4
(R)-3-((S)-but-1-en-3-yl)-8-hydroxy-7-methylisochroman-1-one

: 1278519-69-9
(R)-((2R,S-4S)-2-hydroxy-4-((R)-8-(4-methoxybenzyloxy)-7-methyl-1-oxoisochroman-3-yl)pentyl) 2-methylpent-4-ynoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 24 h / 55 °C

2.1: Wilkinson's catalyst / tetrahydrofuran / 0.17 h

2.2: 22 h / 20 °C

3.1: dihydrogen peroxide; sodium hydroxide / water / 0.5 h / 0 °C

4.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

5.1: potassium tert-butylate / diethyl ether / 0 - 20 °C

5.2: 0 - 20 °C

6.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetonitrile; benzene / 2 h / 0 °C

7.1: dmap; diisopropyl-carbodiimide / dichloromethane / 0.5 h / -40 - 20 °C

With dmap; Wilkinson's catalyst; osmium(VIII) oxide; potassium tert-butylate; dihydrogen peroxide; sodium hydride; Dess-Martin periodane; 4-methylmorpholine N-oxide; sodium hydroxide; diisopropyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil; benzene; 5.2: Wittig reaction / 6.1: Upjohn reaction;
DOI:10.1021/ol200331u

Reference yield:

: 1278519-66-6
(R)-3-((S)-1-hydroxybutan-3-yl)-8-(4-methoxybenzyloxy)-7-methylisochroman-1-one

: 1278519-69-9
(R)-((2R,S-4S)-2-hydroxy-4-((R)-8-(4-methoxybenzyloxy)-7-methyl-1-oxoisochroman-3-yl)pentyl) 2-methylpent-4-ynoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Dess-Martin periodane / dichloromethane / 0 - 20 °C

2.1: potassium tert-butylate / diethyl ether / 0 - 20 °C

2.2: 0 - 20 °C

3.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; acetonitrile; benzene / 2 h / 0 °C

4.1: dmap; diisopropyl-carbodiimide / dichloromethane / 0.5 h / -40 - 20 °C

With dmap; osmium(VIII) oxide; potassium tert-butylate; Dess-Martin periodane; 4-methylmorpholine N-oxide; diisopropyl-carbodiimide; In diethyl ether; dichloromethane; water; acetonitrile; benzene; 2.2: Wittig reaction / 3.1: Upjohn reaction;
DOI:10.1021/ol200331u