(R)-3-((S)-1-hydroxybutan-3-yl)-8-(4-methoxybenzyloxy)-7-methylisochroman-1-one

Base Information

Chemical Name:(R)-3-((S)-1-hydroxybutan-3-yl)-8-(4-methoxybenzyloxy)-7-methylisochroman-1-one
CAS No.:1278519-66-6
Molecular Formula:C₂₂H₂₆O₅
Molecular Weight:370.445
Hs Code.:

Synonyms:(R)-3-((S)-1-hydroxybutan-3-yl)-8-(4-methoxybenzyloxy)-7-methylisochroman-1-one

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Chemical Property of (R)-3-((S)-1-hydroxybutan-3-yl)-8-(4-methoxybenzyloxy)-7-methylisochroman-1-one

Chemical Property:

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Technology Process of (R)-3-((S)-1-hydroxybutan-3-yl)-8-(4-methoxybenzyloxy)-7-methylisochroman-1-one

There total 6 articles about (R)-3-((S)-1-hydroxybutan-3-yl)-8-(4-methoxybenzyloxy)-7-methylisochroman-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₃₇BO₆

: 1278519-66-6
(R)-3-((S)-1-hydroxybutan-3-yl)-8-(4-methoxybenzyloxy)-7-methylisochroman-1-one

Guidance literature:: With dihydrogen peroxide; sodium hydroxide; In water; at 0 ℃; for 0.5h;
DOI:10.1021/ol200331u

Reference yield:

: 1278519-63-3
(R)-3-((S)-but-1-en-3-yl)-7-methyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isochroman-1-one

: 1278519-66-6
(R)-3-((S)-1-hydroxybutan-3-yl)-8-(4-methoxybenzyloxy)-7-methylisochroman-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 2 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

2.2: 24 h / 55 °C

3.1: Wilkinson's catalyst / tetrahydrofuran / 0.17 h

3.2: 22 h / 20 °C

4.1: dihydrogen peroxide; sodium hydroxide / water / 0.5 h / 0 °C

With Wilkinson's catalyst; dihydrogen peroxide; sodium hydride; sodium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ol200331u

Reference yield:

: C₁₄H₁₇BrO₂

: 1278519-66-6
(R)-3-((S)-1-hydroxybutan-3-yl)-8-(4-methoxybenzyloxy)-7-methylisochroman-1-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 2.5 h / 110 °C

2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); triethylamine / 1,4-dioxane / 2 h / 110 °C

3.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; water / 2 h

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

4.2: 24 h / 55 °C

5.1: Wilkinson's catalyst / tetrahydrofuran / 0.17 h

5.2: 22 h / 20 °C

6.1: dihydrogen peroxide; sodium hydroxide / water / 0.5 h / 0 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro bis(acetonitrile) palladium(II); Wilkinson's catalyst; dihydrogen peroxide; sodium hydride; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/ol200331u