benzyl 3-[1-(2-{[4-((E)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]-5-nitrobenzoate

Base Information

Chemical Name:benzyl 3-[1-(2-{[4-((E)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]-5-nitrobenzoate
CAS No.:618398-67-7
Molecular Formula:C₄₀H₃₈N₆O₈
Molecular Weight:730.777
Hs Code.:

benzyl 3-[1-(2-{[4-((E)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]-5-nitrobenzoate

Synonyms:benzyl 3-[1-(2-{[4-((E)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]-5-nitrobenzoate

Suppliers and Price of benzyl 3-[1-(2-{[4-((E)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]-5-nitrobenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl 3-[1-(2-{[4-((E)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]-5-nitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl 3-[1-(2-{[4-((E)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]-5-nitrobenzoate

There total 18 articles about benzyl 3-[1-(2-{[4-((E)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]-5-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: benzyl amino[4-(aminomethyl)phenyl]methylenecarbamate

: 618398-57-5
[6-{3-[(benzyloxy)carbonyl]-5-nitrophenyl}-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetic acid

: 618398-67-7
benzyl 3-[1-(2-{[4-((E)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]-5-nitrobenzoate

Guidance literature:: With 4-methyl-morpholine; polystyrene-carbodiimide; benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; for 13h;
DOI:10.1021/jm0301686

Reference yield: 87.0%

: benzyl amino[4-(aminomethyl)phenyl]methylenecarbamate

: 618398-57-5
[6-{3-[(benzyloxy)carbonyl]-5-nitrophenyl}-3-(isopropylamino)-2-oxopyridin-1(2H)-yl]acetic acid

: 618398-67-7
benzyl 3-[1-(2-{[4-((E)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]-5-nitrobenzoate

Guidance literature:: With 4-methyl-morpholine; polystyrene-carbodiimide; benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; for 13h;
DOI:10.1016/S0040-4020(03)01239-0

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 618398-67-7
benzyl 3-[1-(2-{[4-((E)-amino{[(benzyloxy)carbonyl]imino}methyl)benzyl]amino}-2-oxoethyl)-5-(isopropylamino)-6-oxo-1,6-dihydropyridin-2-yl]-5-nitrobenzoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: NO₂BF₄ / acetonitrile / Heating

2.1: 87 percent / Fe; glacial AcOH / 0.25 h / 80 °C

3.1: 84 percent / dioxane / 48 h / Heating

4.1: TiCl₄ / CH₂Cl₂ / 3 h / 20 °C

5.1: 5.7 g / NaCNBH₃ / CH₂Cl₂ / 14 h / 20 °C

6.1: 78 percent / BBr₃ / CH₂Cl₂ / 16 h / 20 °C

7.1: CaH₂ / tetrahydrofuran / 0.5 h / Heating

7.2: 66 percent / tetrahydrofuran / 18 h / Heating

8.1: 78 percent / Pd(PPh₃)4; Cs₂CO₃ / dioxane / 16 h / 80 °C

9.1: aq. HCl / dioxane / 22 h / 20 °C

10.1: 87 percent / polystyrene-carbodiimide; 1-hydroxybenzotriazole; N-methylmorpholine / CH₂Cl₂; dimethylformamide / 13 h

With 4-methyl-morpholine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; calcium hydride; nitronium tetrafluoborate; polystyrene-carbodiimide; boron tribromide; titanium tetrachloride; iron; sodium cyanoborohydride; benzotriazol-1-ol; caesium carbonate; acetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 8.1: Suzuki coupling;
DOI:10.1021/jm0301686