Technology Process of 4-{[4-cyano-4-(pyridin-4-yl)piperidin-1-yl]methyl}-N-[(1S,2S)-2-hydroxycyclohexyl]quinoline-2-carboxamide
There total 6 articles about 4-{[4-cyano-4-(pyridin-4-yl)piperidin-1-yl]methyl}-N-[(1S,2S)-2-hydroxycyclohexyl]quinoline-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: phosphorus(V) oxybromide / toluene; acetonitrile / 1.5 h / 75 °C
2.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine / 1,4-dioxane; water / 0.5 h / 140 °C / Microwave irradiation
3.1: ozone / dichloromethane / 0.17 h / -78 °C
3.2: polymer-supported triphenylphosphine / 20 °C
4.1: methanol; sodium hydroxide / water; tetrahydrofuran / 3 h
5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 1.5 h / 20 °C
6.1: sodium tris(acetoxy)borohydride; triethylamine / 1,2-dichloro-ethane / 20 °C
With
methanol; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); sodium tris(acetoxy)borohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ozone; triethylamine; sodium hydroxide; phosphorus(V) oxybromide; tricyclohexylphosphine;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane; toluene; acetonitrile;
- Guidance literature:
-
With
sodium tris(acetoxy)borohydride; triethylamine;
In
1,2-dichloro-ethane;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine / 1,4-dioxane; water / 0.5 h / 140 °C / Microwave irradiation
2.1: ozone / dichloromethane / 0.17 h / -78 °C
2.2: polymer-supported triphenylphosphine / 20 °C
3.1: methanol; sodium hydroxide / water; tetrahydrofuran / 3 h
4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / dichloromethane / 1.5 h / 20 °C
5.1: sodium tris(acetoxy)borohydride; triethylamine / 1,2-dichloro-ethane / 20 °C
With
methanol; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); sodium tris(acetoxy)borohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ozone; triethylamine; sodium hydroxide; tricyclohexylphosphine;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 1,2-dichloro-ethane;
