1-Bromo-2-(difluoromethyl)benzene

Base Information

Chemical Name:1-Bromo-2-(difluoromethyl)benzene
CAS No.:845866-82-2
Molecular Formula:C7H5 Br F2
Molecular Weight:207.018
Hs Code.:2903999090
European Community (EC) Number:641-168-0
DSSTox Substance ID:DTXSID80375607
Nikkaji Number:J3.535.179E
Wikidata:Q82164201
Mol file:845866-82-2.mol

Synonyms:1-bromo-2-(difluoromethyl)benzene;845866-82-2;1-Bromo-2-difluoromethylbenzene;2-(difluoromethyl)bromobenzene;MFCD06657962;Benzene,1-bromo-2-(difluoromethyl)-;SCHEMBL183025;1-bromo-2-difluoromethyl-benzene;DTXSID80375607;AMY28139;BBL101526;STL555322;AKOS005259017;1-Bromo-2-difluoromethylbenzene, 97%;CS-W000083;FS-4210;s10423;SY035109;1-Bromo-2-difluoromethylbenzene, AldrichCPR;FT-0644900;J3.535.179E;EN300-130238;1-Bromo-2-difluoromethylbenzene stabilized over potassium carbonate;1-Bromo-2-(difluoromethyl)benzene (stabilised over Potassium Carbonate);(2S,4S)-1-(TERT-BUTOXYCARBONYL)-4-(2-NAPHTHYLOXY)-2-PYRROLIDINECARBOXYLICACID

Suppliers and Price of 1-Bromo-2-(difluoromethyl)benzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-Bromo-2-difluoromethylbenzene
250mg
$ 55.00

SynQuest Laboratories
1-Bromo-2-(difluoromethyl)benzene 97%
100 g
$ 695.00

SynQuest Laboratories
1-Bromo-2-(difluoromethyl)benzene 97%
25 g
$ 195.00

SynQuest Laboratories
1-Bromo-2-(difluoromethyl)benzene 97%
5 g
$ 45.00

SynQuest Laboratories
1-Bromo-2-(difluoromethyl)benzene 97%
1 g
$ 15.00

Sigma-Aldrich
1-Bromo-2-difluoromethylbenzene 97%
5g
$ 105.00

Sigma-Aldrich
1-Bromo-2-difluoromethylbenzene Aldrich
100mg
$ 53.00

Sigma-Aldrich
1-Bromo-2-difluoromethylbenzene 97%
1g
$ 32.60

Matrix Scientific
1-Bromo-2-(difluoromethyl)benzene 97%
25g
$ 233.00

Matrix Scientific
1-Bromo-2-(difluoromethyl)benzene 97%
1g
$ 16.00

Total 24 raw suppliers

Chemical Property of 1-Bromo-2-(difluoromethyl)benzene

Chemical Property:

Vapor Pressure:0.539mmHg at 25°C
Refractive Index:1.498
Boiling Point:197.2°C at 760 mmHg
Flash Point:73.1°C
PSA：0.00000
Density:1.597 g/mL at 25 °C
LogP:3.38670
Storage Temp.:2-8°C(protect from light)
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:205.95427
Heavy Atom Count:10
Complexity:106

Purity/Quality:

97% ^*data from raw suppliers

1-Bromo-2-difluoromethylbenzene ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi,N
Hazard Codes:Xi,N
Statements: 36/37/38-51/53
Safety Statements: 26-61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(F)F)Br

Technology Process of 1-Bromo-2-(difluoromethyl)benzene

There total 3 articles about 1-Bromo-2-(difluoromethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 6630-33-7
ortho-bromobenzaldehyde

: 845866-82-2
1-bromo-2-(difluoromethyl)benzene

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at 0 - 20 ℃;

Reference yield: 46.0%

: 583-55-1
1-Bromo-2-iodobenzene

: [bis(difluoromethyl)zinc(dmpu)₂]

: 845866-82-2
1-bromo-2-(difluoromethyl)benzene

Guidance literature:: With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; copper(l) iodide; at 60 ℃; for 24h; Inert atmosphere;
DOI:10.1021/acs.orglett.6b01733

Reference yield: 33.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 244205-40-1
(2-bromophenyl)boronic acid

: 845866-82-2
1-bromo-2-(difluoromethyl)benzene

Guidance literature:: With styrene; bis-triphenylphosphine-palladium(II) chloride; iron(III)-acetylacetonate; potassium carbonate; hydroquinone; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 80 ℃; for 24h; Schlenk technique; Glovebox;
DOI:10.1021/acs.orglett.5b03206