2-(2-(DIFLUOROMETHYL)PHENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE

Base Information

• Chemical Name: 2-(2-(DIFLUOROMETHYL)PHENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE
• CAS No.: 879275-72-6
• Molecular Formula: C₁₃H₁₇BF₂O₂
• Molecular Weight: 254.085
• Hs Code.: 2931900090
• Mol file: 879275-72-6.mol

Synonyms:2-[2-(difluoromethyl)-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Chemical Property of 2-(2-(DIFLUOROMETHYL)PHENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE

Chemical Property:

• Boiling Point: 316.1±37.0 °C(Predicted)
• Density: 1.09±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

2-(Difluoromethyl)benzene boronic acid, pinacol ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-(DIFLUOROMETHYL)PHENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE

There total 6 articles about 2-(2-(DIFLUOROMETHYL)PHENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

1-bromo-2-(difluoromethyl)benzene (845866-82-2) + bis(pinacol)diborane (73183-34-3) → 2-[2-(difluoromethyl)-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (879275-72-6)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere;

Reference yield: 69.0%

2,2-difluoro-2-(2-iodophenyl)-1-phenylethan-1-one + bis(pinacol)diborane (73183-34-3) → 2-[2-(difluoromethyl)-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (879275-72-6)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; potassium tert-butylate; In 1,4-dioxane; at 80 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1002/anie.201900745

Reference yield: 59.0%

1-bromo-2-(difluoromethyl)benzene (845866-82-2) + 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (61676-62-8) → 2-[2-(difluoromethyl)-phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (879275-72-6)

Guidance literature:

1-bromo-2-(difluoromethyl)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; hexane; at -78 - 20 ℃;

upstream raw materials:

1-bromo-2-(difluoromethyl)benzene

2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

bis(pinacol)diborane

[bis(acetoxy)iodo]benzene

Downstream raw materials:

isobutyl (R)-1-(2-(2-(difluoromethyl)phenyl)-7-methylquinazolin-4-yl)pyrrolidin-3-ylcarbamate

neopentyl (R)-1-(2-(2-(difluoromethyl)phenyl)-7-methylquinazolin-4-yl)pyrrolidin-3-ylcarbamate

isobutyl 4-(4-(2-(difluoromethyl)phenyl)pyrimidin-2-yl)piperazine-1-carboxylate

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