(3S,6S,9R,1'R)-3-[9'-fluorenylmethyloxycarbonyl]-9-[(1'-carbamoyl-2'-phenyl)ethyl]carbamoyl-2-oxo-7-thio-1-azabicyclo[4.3.0]nonane

Base Information

Chemical Name:(3S,6S,9R,1'R)-3-[9'-fluorenylmethyloxycarbonyl]-9-[(1'-carbamoyl-2'-phenyl)ethyl]carbamoyl-2-oxo-7-thio-1-azabicyclo[4.3.0]nonane
CAS No.:872035-23-9
Molecular Formula:C₃₂H₃₂N₄O₅S
Molecular Weight:584.696
Hs Code.:

Synonyms:(3S,6S,9R,1'R)-3-[9'-fluorenylmethyloxycarbonyl]-9-[(1'-carbamoyl-2'-phenyl)ethyl]carbamoyl-2-oxo-7-thio-1-azabicyclo[4.3.0]nonane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,6S,9R,1'R)-3-[9'-fluorenylmethyloxycarbonyl]-9-[(1'-carbamoyl-2'-phenyl)ethyl]carbamoyl-2-oxo-7-thio-1-azabicyclo[4.3.0]nonane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3S,6S,9R,1'R)-3-[9'-fluorenylmethyloxycarbonyl]-9-[(1'-carbamoyl-2'-phenyl)ethyl]carbamoyl-2-oxo-7-thio-1-azabicyclo[4.3.0]nonane

There total 1 articles about (3S,6S,9R,1'R)-3-[9'-fluorenylmethyloxycarbonyl]-9-[(1'-carbamoyl-2'-phenyl)ethyl]carbamoyl-2-oxo-7-thio-1-azabicyclo[4.3.0]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5241-58-7,5241-59-8,17193-31-6,60058-39-1
D-Phenylalaninamide

: 149563-21-3
Fmoc-β-turn-dipeptide

: 872035-23-9
(3S,6S,9R,1'R)-3-[9'-fluorenylmethyloxycarbonyl]-9-[(1'-carbamoyl-2'-phenyl)ethyl]carbamoyl-2-oxo-7-thio-1-azabicyclo[4.3.0]nonane

Guidance literature:: With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane;
DOI:10.1021/jm050689o

Reference yield:

: 872035-23-9
(3S,6S,9R,1'R)-3-[9'-fluorenylmethyloxycarbonyl]-9-[(1'-carbamoyl-2'-phenyl)ethyl]carbamoyl-2-oxo-7-thio-1-azabicyclo[4.3.0]nonane

: (3R,6S,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a]pyridine-3-carboxylic acid ((R)-1-carbamoyl-2-phenyl-ethyl)-amide

Guidance literature:: With piperidine; In tetrahydrofuran; for 2h;
DOI:10.1021/jm050689o

Reference yield:

: 872035-23-9
(3S,6S,9R,1'R)-3-[9'-fluorenylmethyloxycarbonyl]-9-[(1'-carbamoyl-2'-phenyl)ethyl]carbamoyl-2-oxo-7-thio-1-azabicyclo[4.3.0]nonane

: [1-[3-(1-carbamoyl-2-phenyl-ethylcarbamoyl)-5-oxo-hexahydro-thiazolo[3,2-a]pyridin-6-ylcarbamoyl]-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / tetrahydrofuran / 2 h

2: BOP; TEA / CH₂Cl₂

With piperidine; TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050689o