4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoic acid

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Chemical Name:4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoic acid
CAS No.:1562995-30-5
Molecular Formula:C₂₄H₁₆ClF₂N₃O₃
Molecular Weight:467.859
Hs Code.:

Synonyms:4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoic acid

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Chemical Property of 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoic acid

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Technology Process of 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoic acid

There total 11 articles about 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.8%

: 1562995-76-9
ethyl 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoate

: 1562995-30-5
4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; methanol; at 10 ℃; for 2h;

Reference yield:

: 1561772-12-0
2-chloro-6-cyclobutylbenzoic acid

: 1562995-30-5
4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 10 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 2 h / 10 °C

3.1: potassium phosphate; C₃₈H₄₆ClNO₂PPd / toluene; water / 16 h / 10 °C

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 10 °C

With potassium phosphate; oxalyl dichloride; C₃₈H₄₆ClNO₂PPd; water; sodium hydride; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1562995-65-6
2-chloro-6-cyclobutylbenzoyl chloride

: 1562995-30-5
4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 2 h / 10 °C

2.1: potassium phosphate; C₃₈H₄₆ClNO₂PPd / toluene; water / 16 h / 10 °C

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 10 °C

With potassium phosphate; C₃₈H₄₆ClNO₂PPd; water; sodium hydride; lithium hydroxide; In tetrahydrofuran; methanol; water; toluene; mineral oil;