ethyl 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoate

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Chemical Name:ethyl 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoate
CAS No.:1562995-76-9
Molecular Formula:C₂₆H₂₀ClF₂N₃O₃
Molecular Weight:495.913
Hs Code.:

Synonyms:ethyl 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoate

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Chemical Property of ethyl 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoate

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Technology Process of ethyl 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoate

There total 10 articles about ethyl 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.4%

: 1562995-66-7
(2-chloro-6-cyclobutylphenyl)(3-iodo-1H-pyrazolo[4,3-b]pyridin-1-yl)methanone

: 1562995-71-4
ethyl 3,5-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

: 1562995-76-9
ethyl 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoate

Guidance literature:: With potassium phosphate; C₃₈H₄₆ClNO₂PPd; In water; toluene; at 10 ℃; for 16h;

Reference yield:

: 1561772-12-0
2-chloro-6-cyclobutylbenzoic acid

: 1562995-76-9
ethyl 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 3 h / 10 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 2 h / 10 °C

3.1: potassium phosphate; C₃₈H₄₆ClNO₂PPd / toluene; water / 16 h / 10 °C

With potassium phosphate; oxalyl dichloride; C₃₈H₄₆ClNO₂PPd; sodium hydride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1562995-65-6
2-chloro-6-cyclobutylbenzoyl chloride

: 1562995-76-9
ethyl 4-(1-(2-chloro-6-cyclobutylbenzoyl)-1H-pyrazolo[4,3-b]pyridin-3-yl)-3,5-difluorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

1.2: 2 h / 10 °C

2.1: potassium phosphate; C₃₈H₄₆ClNO₂PPd / toluene; water / 16 h / 10 °C

With potassium phosphate; C₃₈H₄₆ClNO₂PPd; sodium hydride; In tetrahydrofuran; water; toluene; mineral oil;