methyl 3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

Base Information

Chemical Name:methyl 3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate
CAS No.:1445791-12-7
Molecular Formula:C₃₆H₄₁N₅O₆
Molecular Weight:639.751
Hs Code.:

Synonyms:methyl 3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

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Chemical Property of methyl 3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

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Technology Process of methyl 3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

There total 13 articles about methyl 3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1445791-10-5
methyl 3-(3-carbamoyl-7-chloro-6-(cyclohexylmethoxy)quinolin-4-ylamino)-5-cyclopentylbenzoate

: 89641-18-9
2,4-dimethoxypyrimidin-5-ylboronic acid

: 1445791-12-7
methyl 3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;

Reference yield:

: C₁₁H₇Cl₂NO₃

: 1445791-12-7
methyl 3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium hydroxide / tetrahydrofuran / 0 °C

2.1: boron tribromide / 1,2-dichloro-ethane / 0 - 75 °C / Inert atmosphere

2.2: 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 50 °C

4.1: ethanol / Reflux

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 7-chloro-4-hydroxy-6-methoxyquinoline-3-carboxylic acid

: 1445791-12-7
methyl 3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate; water / 3 h / Reflux

2.1: ammonium hydroxide / tetrahydrofuran / 0 °C

3.1: boron tribromide / 1,2-dichloro-ethane / 0 - 75 °C / Inert atmosphere

3.2: 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 50 °C

5.1: ethanol / Reflux

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; boron tribromide; sodium hydrogencarbonate; potassium carbonate; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;