3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Base Information

Chemical Name:3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoic acid
CAS No.:1445787-64-3
Molecular Formula:C₃₅H₃₉N₅O₆
Molecular Weight:625.725
Hs Code.:

Synonyms:3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoic acid

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Chemical Property of 3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoic acid

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Technology Process of 3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoic acid

There total 14 articles about 3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1445791-12-7
methyl 3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoate

: 1445787-64-3
3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 20 ℃; for 5h;

Reference yield:

: 7-chloro-4-hydroxy-6-methoxyquinoline-3-carboxylic acid

: 1445787-64-3
3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: trichlorophosphate; water / 3 h / Reflux

2.1: ammonium hydroxide / tetrahydrofuran / 0 °C

3.1: boron tribromide / 1,2-dichloro-ethane / 0 - 75 °C / Inert atmosphere

3.2: 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 50 °C

5.1: ethanol / Reflux

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere

7.1: sodium hydroxide; water / methanol / 5 h / 20 °C

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; boron tribromide; sodium hydrogencarbonate; potassium carbonate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: C₁₁H₇Cl₂NO₃

: 1445787-64-3
3-((3-carbamoyl-6-(cyclohexylmethoxy)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium hydroxide / tetrahydrofuran / 0 °C

2.1: boron tribromide / 1,2-dichloro-ethane / 0 - 75 °C / Inert atmosphere

2.2: 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 50 °C

4.1: ethanol / Reflux

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere

6.1: sodium hydroxide; water / methanol / 5 h / 20 °C

With ammonium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; boron tribromide; sodium hydrogencarbonate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;