diethyl (3-bromo-4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Base Information

Chemical Name:diethyl (3-bromo-4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate
CAS No.:1380305-76-9
Molecular Formula:C₁₆H₁₇BrClF₃N₃O₃P
Molecular Weight:502.655
Hs Code.:

Synonyms:diethyl (3-bromo-4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Suppliers and Price of diethyl (3-bromo-4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diethyl (3-bromo-4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diethyl (3-bromo-4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

There total 3 articles about diethyl (3-bromo-4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1257996-86-3
diethyl (4-amino-3-bromobenzyl)phosphonate

: 3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine

: 1380305-76-9
diethyl (3-bromo-4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Guidance literature:: 2,4-dichloro-5-trifluoromethylpyrimidine; With zinc(II) chloride; In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol; at 20 ℃; for 0.5h; Inert atmosphere;

diethyl (4-amino-3-bromobenzyl)phosphonate; In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol; at 0 ℃; for 1.16667h;

With N-ethyl-N,N-diisopropylamine; In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol; at 20 ℃; for 72h;

Reference yield:

: 1257996-87-4
di-tert-butyl [2-bromo-4-(bromomethyl)phenyl]imidodicarbonate

: 1380305-76-9
diethyl (3-bromo-4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 20 h / 120 - 150 °C / Microwave irradiation

2.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h / 20 °C / Inert atmosphere

2.2: 1.17 h / 0 °C

2.3: 72 h / 20 °C

With zinc(II) chloride; In diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol;

Reference yield:

: 880384-50-9
di-tert-butyl (2-bromo-4-methylphenyl)imidodicarbonate

: 1380305-76-9
diethyl (3-bromo-4-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / α,α,α-trifluorotoluene / 3 h / 80 °C / Inert atmosphere

2.1: 20 h / 120 - 150 °C / Microwave irradiation

3.1: zinc(II) chloride / diethyl ether; 1,2-dichloro-ethane; tert-butyl alcohol / 0.5 h / 20 °C / Inert atmosphere

3.2: 1.17 h / 0 °C

3.3: 72 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); zinc(II) chloride; In diethyl ether; α,α,α-trifluorotoluene; 1,2-dichloro-ethane; tert-butyl alcohol;