2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]-2-N-(phenylacetyl)guanosine

Base Information

Chemical Name:2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]-2-N-(phenylacetyl)guanosine
CAS No.:263009-03-6
Molecular Formula:C₃₁H₃₅ClN₆O₇
Molecular Weight:639.108
Hs Code.:

Synonyms:2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]-2-N-(phenylacetyl)guanosine

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Chemical Property of 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]-2-N-(phenylacetyl)guanosine

Chemical Property:

Purity/Quality:

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Technology Process of 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]-2-N-(phenylacetyl)guanosine

There total 8 articles about 2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]-2-N-(phenylacetyl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1054635-91-4
2'-O-[1-(4-chlorophenyl)-4-ethoxypiperidin-4-yl]-2-N-phenylacetyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxyl)guanosine

: 263009-03-6
2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]-2-N-(phenylacetyl)guanosine

Guidance literature:: With tetraethylammonium fluoride; In acetonitrile; at 20 ℃; for 0.75h;
DOI:10.1039/a908149f

Reference yield:

: 106-47-8
4-chloro-aniline

: 263009-03-6
2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]-2-N-(phenylacetyl)guanosine

Guidance literature:: Multi-step reaction with 5 steps

1: TsOH*H₂O / ethanol / 1.5 h / Heating

2: TsOH / ethanol / 0.5 h / Heating

3: 93 percent / DIPEA; BF₃*OEt₂ / CH₂Cl₂ / 2 h / 0 °C

4: TFA / CH₂Cl₂ / 3 h / 20 °C

5: Et₄NF / acetonitrile / 0.75 h / 20 °C

With boron trifluoride diethyl etherate; tetraethylammonium fluoride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; acetonitrile; 1: Alkylation / 2: Etherification / 3: Elimination / 4: Addition / 5: Desilylation;
DOI:10.1039/a908149f

Reference yield:

: 3592-25-4
1,5-dichloropentan-3-one

: 263009-03-6
2'-O-[1-(4-Chlorophenyl)-4-ethoxypiperidin-4-yl]-2-N-(phenylacetyl)guanosine

Guidance literature:: Multi-step reaction with 5 steps

1: TsOH*H₂O / ethanol / 1.5 h / Heating

2: TsOH / ethanol / 0.5 h / Heating

3: 93 percent / DIPEA; BF₃*OEt₂ / CH₂Cl₂ / 2 h / 0 °C

4: TFA / CH₂Cl₂ / 3 h / 20 °C

5: Et₄NF / acetonitrile / 0.75 h / 20 °C

With boron trifluoride diethyl etherate; tetraethylammonium fluoride; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In ethanol; dichloromethane; acetonitrile; 1: Alkylation / 2: Etherification / 3: Elimination / 4: Addition / 5: Desilylation;
DOI:10.1039/a908149f