3-(2-((tert-butyldimethylsilyl)oxy)phenyl)propan-1-ol

Base Information

• Chemical Name: 3-(2-((tert-butyldimethylsilyl)oxy)phenyl)propan-1-ol
• CAS No.: 327155-45-3
• Molecular Formula: C₁₅H₂₆O₂Si
• Molecular Weight: 266.456
• Mol file: 327155-45-3.mol

Synonyms:3-(2-((tert-butyldimethylsilyl)oxy)phenyl)propan-1-ol

Chemical Property of 3-(2-((tert-butyldimethylsilyl)oxy)phenyl)propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-((tert-butyldimethylsilyl)oxy)phenyl)propan-1-ol

There total 6 articles about 3-(2-((tert-butyldimethylsilyl)oxy)phenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-tert-butyldimethylsilyloxy-2-(2-propenyl)benzene (151950-94-6) → 3-(2-((tert-butyldimethylsilyl)oxy)phenyl)propan-1-ol (327155-45-3)

Guidance literature:

1-tert-butyldimethylsilyloxy-2-(2-propenyl)benzene; With 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; at 0 - 20 ℃; for 6h; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c8ob01143e

Reference yield: 57.0%

3-(2-((tert-butyldimethylsilyl)oxy)phenyl)propylacetate → 3-(2-((tert-butyldimethylsilyl)oxy)phenyl)propan-1-ol (327155-45-3)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jacs.9b04142 DOI:10.1021/jacs.9b04142

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 3-(2-((tert-butyldimethylsilyl)oxy)phenyl)propan-1-ol (327155-45-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Et₃N, 4-(dimethylamino)pyridine / CH₂Cl₂ / Ambient temperature

2: 1.) BH₃*THF, 2.) aq. NaOH, H₂O₂ / 1.) THF, room temperature, 2 h, 2.) 0 deg C, 3 h

With dmap; sodium hydroxide; borane-THF; dihydrogen peroxide; triethylamine; In dichloromethane;

DOI:10.1021/jo961832b

upstream raw materials:

1-tert-butyldimethylsilyloxy-2-(2-propenyl)benzene

tert-butyldimethylsilyl chloride

o-Allylphenol

Downstream raw materials:

3-<2-<(tert-butyldimethylsilyl)oxy>phenyl>-1-iodopropane

3-(2-((tertbutyldimethylsilyl)oxy)phenyl)propanal

tert-butyl-[2-(3-cyclopropylidene-propyl)-phenoxy]-dimethyl-silane

4-(2-hydroxyphenyl)-1-butyne