N-Ethyl 5-bromopicolinamide

Base Information

• Chemical Name: N-Ethyl 5-bromopicolinamide
• CAS No.: 845305-88-6
• Molecular Formula: C₈H₉BrN₂O
• Molecular Weight: 229.076
• Hs Code.: 2933399090
• Mol file: 845305-88-6.mol

Synonyms:5-Bromo-N-ethylpyridine-2-carboxamide;5-Bromopyridine-2-carboxylic acid ethylamide

Chemical Property of N-Ethyl 5-bromopicolinamide

Chemical Property:

• Vapor Pressure: 3.21E-05mmHg at 25°C
• Refractive Index: 1.559
• Boiling Point: 355.1ºC at 760 mmHg
• Flash Point: 168.5ºC
• PSA: 41.99000
• Density: 1.471g/cm3
• LogP: 1.98470
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N-Ethyl 5-bromopicolinamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Ethyl 5-bromopicolinamide

There total 2 articles about N-Ethyl 5-bromopicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromoisonicotinic acid (30766-11-1) + ethylamine (75-04-7,85404-22-4) → 5-bromo-pyridine-2-carboxylic acid ethylamide (845305-88-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; water; at 50 ℃;

Reference yield:

→ 5-bromo-pyridine-2-carboxylic acid ethylamide (845305-88-6)

Guidance literature:

Reference yield:

5-bromo-pyridine-2-carboxylic acid ethylamide (845305-88-6) → 5-(3-{[2,6-difluoro-3-(propane-1-sulfonylamino)-phenyl]-hydroxy-methyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-pyridine-2-carboxylic acid ethylamide (1254566-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water / 80 °C

2: potassium hydroxide / methanol / 2 h / 20 °C

With potassium carbonate; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water;

upstream raw materials:

5-bromoisonicotinic acid

ethylamine

Downstream raw materials:

5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine-2-carboxylic acid ethylamide

5-(3-{[2,6-difluoro-3-(propane-1-sulfonylamino)-phenyl]-hydroxy-methyl}-1H-pyrrolo[2,3-b]pyridin-5-yl)-pyridine-2-carboxylic acid ethylamide

5-{3-[2,6-difluoro-3-(propane-1-sulfonylamino)-benzoyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-pyridine-2-carboxylic acid ethylamide