4-(2,2-difluorovinyl)-N,N-dipropylbenzamide

Base Information

Chemical Name:4-(2,2-difluorovinyl)-N,N-dipropylbenzamide
CAS No.:1620096-51-6
Molecular Formula:C₁₅H₁₉F₂NO
Molecular Weight:267.319
Hs Code.:

Synonyms:4-(2,2-difluorovinyl)-N,N-dipropylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(2,2-difluorovinyl)-N,N-dipropylbenzamide

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Technology Process of 4-(2,2-difluorovinyl)-N,N-dipropylbenzamide

There total 3 articles about 4-(2,2-difluorovinyl)-N,N-dipropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 80020-16-2
4-formyl-N,N-dipropylbenzamide

: 2,2‐difluoro‐2‐(triphenylphosphonio)acetate

: 1620096-51-6
4-(2,2-difluorovinyl)-N,N-dipropylbenzamide

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.orglett.7b00386

Reference yield:

: 142-84-7
di-n-propylamine

: 1620096-51-6
4-(2,2-difluorovinyl)-N,N-dipropylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / toluene / 1 h / Reflux

1.2: 0 - 20 °C

2.1: 1-methyl-pyrrolidin-2-one / 2 h / 80 °C / Inert atmosphere

With thionyl chloride; In 1-methyl-pyrrolidin-2-one; toluene;
DOI:10.1021/acs.orglett.7b00386

Reference yield:

: 16173-52-7
4-formylbenzoyl chloride

: 1620096-51-6
4-(2,2-difluorovinyl)-N,N-dipropylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 1 h / 60 °C / Sealed tube; Inert atmosphere

With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo501289v