(S)-2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-3-phenylpropanamide

Base Information

Chemical Name:(S)-2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-3-phenylpropanamide
CAS No.:1383708-62-0
Molecular Formula:C₂₈H₂₄FN₃O₃
Molecular Weight:469.515
Hs Code.:

Synonyms:(S)-2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-3-phenylpropanamide

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Chemical Property of (S)-2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-3-phenylpropanamide

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Technology Process of (S)-2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-3-phenylpropanamide

There total 3 articles about (S)-2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 2018-61-3
(S)-2-acetylamino-3-phenylpropanoic acid

: 1383709-50-9
6-(4-(4-fluorophenoxy)phenyl)pyridin-2-amine

: 1383708-62-0
(S)-2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-3-phenylpropanamide

Guidance literature:: (S)-2-acetylamino-3-phenylpropanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 1h;

6-(4-(4-fluorophenoxy)phenyl)pyridin-2-amine; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

: 19798-81-3,1184170-10-2
2-Amino-6-bromopyridine

: 1383708-62-0
(S)-2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 4 h / Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h

2.2: 48 h / 20 °C

With sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1355052-34-4
2-(4-(4-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1383708-62-0
(S)-2-acetamido-N-(6-(4-(4-fluorophenoxy)phenyl)pyridin-2-yl)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 4 h / Reflux

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h

2.2: 48 h / 20 °C

With sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; water; N,N-dimethyl-formamide;