dimethyl (2E)-2-{3-[(4-methoxybenzyl)oxy]propylidene}succinate

Base Information

• Chemical Name: dimethyl (2E)-2-{3-[(4-methoxybenzyl)oxy]propylidene}succinate
• CAS No.: 1320319-30-9
• Molecular Formula: C₁₇H₂₂O₆
• Molecular Weight: 322.358
• Mol file: 1320319-30-9.mol

Synonyms:dimethyl (2E)-2-{3-[(4-methoxybenzyl)oxy]propylidene}succinate

Chemical Property of dimethyl (2E)-2-{3-[(4-methoxybenzyl)oxy]propylidene}succinate

Chemical Property:

Purity/Quality:

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Technology Process of dimethyl (2E)-2-{3-[(4-methoxybenzyl)oxy]propylidene}succinate

There total 1 articles about dimethyl (2E)-2-{3-[(4-methoxybenzyl)oxy]propylidene}succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3-(p-methoxybenzyloxy)propanal (128461-65-4) + dimethyl cis-but-2-ene-1,4-dioate (624-48-6) → dimethyl (2E)-2-{3-[(4-methoxybenzyl)oxy]propylidene}succinate (1320319-30-9)

Guidance literature:

With tributylphosphine; In tetrahydrofuran; at 20 ℃; for 30h; Inert atmosphere;

DOI:10.1055/s-0030-1260013

Reference yield: 85.0%

dimethyl (2E)-2-{3-[(4-methoxybenzyl)oxy]propylidene}succinate (1320319-30-9) + methyl iodide (74-88-4) → dimethyl (2E)-2-{3-[(4-methoxybenzyl)oxy]propylidene}-3-methylsuccinate (1320319-46-7)

Guidance literature:

dimethyl (2E)-2-{3-[(4-methoxybenzyl)oxy]propylidene}succinate; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; for 0.75h; regioselective reaction; Cooling;

DOI:10.1055/s-0030-1260013

upstream raw materials:

3-(p-methoxybenzyloxy)propanal

dimethyl cis-but-2-ene-1,4-dioate

Downstream raw materials:

dimethyl (2E)-2-{3-[(4-methoxybenzyl)oxy]propylidene}-3-methylsuccinate