6-benzyloxy-5-hydroxy-5-methoxymethyl-3-hexynyl tert-butyldiphenylsilyl ether

Base Information

Chemical Name:6-benzyloxy-5-hydroxy-5-methoxymethyl-3-hexynyl tert-butyldiphenylsilyl ether
CAS No.:264890-73-5
Molecular Formula:C₃₁H₃₈O₄Si
Molecular Weight:502.726
Hs Code.:

Synonyms:6-benzyloxy-5-hydroxy-5-methoxymethyl-3-hexynyl tert-butyldiphenylsilyl ether

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Chemical Property of 6-benzyloxy-5-hydroxy-5-methoxymethyl-3-hexynyl tert-butyldiphenylsilyl ether

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Technology Process of 6-benzyloxy-5-hydroxy-5-methoxymethyl-3-hexynyl tert-butyldiphenylsilyl ether

There total 4 articles about 6-benzyloxy-5-hydroxy-5-methoxymethyl-3-hexynyl tert-butyldiphenylsilyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88158-68-3
4-(tert-butyldiphenylsilyloxy)-1-butyne

: 157372-75-3
1-(benzyloxy)-3-methoxypropan-2-one

: 264890-73-5
6-benzyloxy-5-hydroxy-5-methoxymethyl-3-hexynyl tert-butyldiphenylsilyl ether

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;
DOI:10.1016/S0040-4020(00)00009-0

Reference yield:

: 90904-26-0
4-(1-methoxymethyl)-2-phenyl-1,3-dioxolane

: 264890-73-5
6-benzyloxy-5-hydroxy-5-methoxymethyl-3-hexynyl tert-butyldiphenylsilyl ether

Guidance literature:: Multi-step reaction with 3 steps

1: 2.862 g / Et₃SiH; TiCl₄ / CH₂Cl₂ / 0.5 h / -78 °C

2: 2.095 g / 4-methylmorpholine N-oxide; molecular sieves 4 Angstroem; tetrapropylammonium perruthenate / CH₂Cl₂; acetonitrile / 2 h / 20 °C

3: 2.387 g / BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

With triethylsilane; n-butyllithium; tetrapropylammonium perruthennate; 4 A molecular sieve; titanium tetrachloride; 4-methylmorpholine N-oxide; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; 1: Ring cleavage / 2: Oxidation / 3: Addition;
DOI:10.1016/S0040-4020(00)00009-0

Reference yield:

: 73422-88-5,90904-30-6,103129-24-4,4137-81-9
1-phenylmethyl-3-methoxy-1,2-propanediol

: 264890-73-5
6-benzyloxy-5-hydroxy-5-methoxymethyl-3-hexynyl tert-butyldiphenylsilyl ether

Guidance literature:: Multi-step reaction with 2 steps

1: 2.095 g / 4-methylmorpholine N-oxide; molecular sieves 4 Angstroem; tetrapropylammonium perruthenate / CH₂Cl₂; acetonitrile / 2 h / 20 °C

2: 2.387 g / BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

With n-butyllithium; tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; 1: Oxidation / 2: Addition;
DOI:10.1016/S0040-4020(00)00009-0