4-[4-(tert-butyldiphenylsilyloxy)butyl]-2,2-dimethyl-4-methoxymethyl-1,3-dioxolane

Base Information

• Chemical Name: 4-[4-(tert-butyldiphenylsilyloxy)butyl]-2,2-dimethyl-4-methoxymethyl-1,3-dioxolane
• CAS No.: 264890-91-7
• Molecular Formula: C₂₇H₄₀O₄Si
• Molecular Weight: 456.698
• Mol file: 264890-91-7.mol

Synonyms:4-[4-(tert-butyldiphenylsilyloxy)butyl]-2,2-dimethyl-4-methoxymethyl-1,3-dioxolane

Chemical Property of 4-[4-(tert-butyldiphenylsilyloxy)butyl]-2,2-dimethyl-4-methoxymethyl-1,3-dioxolane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[4-(tert-butyldiphenylsilyloxy)butyl]-2,2-dimethyl-4-methoxymethyl-1,3-dioxolane

There total 2 articles about 4-[4-(tert-butyldiphenylsilyloxy)butyl]-2,2-dimethyl-4-methoxymethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2,2-dimethoxy-propane (77-76-9) + tert-butyldiphenylsilyl 5,6-dihydroxy-5-methoxymethylhexyl ether (264890-74-6) → 4-[4-(tert-butyldiphenylsilyloxy)butyl]-2,2-dimethyl-4-methoxymethyl-1,3-dioxolane (264890-91-7)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(00)00009-0

Reference yield:

6-benzyloxy-5-hydroxy-5-methoxymethyl-3-hexynyl tert-butyldiphenylsilyl ether (264890-73-5) → 4-[4-(tert-butyldiphenylsilyloxy)butyl]-2,2-dimethyl-4-methoxymethyl-1,3-dioxolane (264890-91-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / H₂ / Pd/C / methanol / 20 °C

2: 98 percent / PPTS / CH₂Cl₂ / 1 h / 20 °C

With hydrogen; pyridinium p-toluenesulfonate; palladium on activated charcoal; In methanol; dichloromethane; 1: Hydrogenation / 2: Etherification;

DOI:10.1016/S0040-4020(00)00009-0

upstream raw materials:

2,2-dimethoxy-propane

tert-butyldiphenylsilyl 5,6-dihydroxy-5-methoxymethylhexyl ether

6-benzyloxy-5-hydroxy-5-methoxymethyl-3-hexynyl tert-butyldiphenylsilyl ether