N--5-thiophenoxy-2-pyrrolidinone

Base Information

Chemical Name:N--5-thiophenoxy-2-pyrrolidinone
CAS No.:80664-53-5
Molecular Formula:C₂₀H₂₅NOS
Molecular Weight:327.491
Hs Code.:

N-<rel-(1R,2S,3S)-2,3-divinylcyclohexyl>-5-thiophenoxy-2-pyrrolidinone

Synonyms:N--5-thiophenoxy-2-pyrrolidinone

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Chemical Property of N--5-thiophenoxy-2-pyrrolidinone

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Technology Process of N--5-thiophenoxy-2-pyrrolidinone

There total 6 articles about N--5-thiophenoxy-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 930-68-7
cyclohexenone

: 80664-53-5
N--5-thiophenoxy-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / 1.) aluminum chloride / benzene / 1.) room temperature, 45 min, 2.) 70-75 deg C, 5 h

2: 83 percent / lithium aluminum hydride / tetrahydrofuran / 1.) -70 deg C, 75 min, 2.) 3 h

3: 62 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 1.) 0 deg C, 45 min, 2.) room temperature, 30 min

4: 1.) ozone, 2.) sodium borohydride / methanol / 1.) -78 deg C, 43 min

5: 1.) o-nitrophenyl selenocyanate, tri-n-butylphosphine, 2.) aq. hydrogen peroxide / 1.) THF, 0 deg C, 15 min; room temperature, 45 min, 2.) 0 deg C, 20 min; 30 min

6: 1.) sodium borohydride, hydrochloric acid, pH 3, 2.) p-toluenesulfonic acid / 1.) ethanol, 0 deg C, 4 h, 2.) 30 min

With hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; aluminium trichloride; ortho-nitrophenyl selenocyanate; tributylphosphine; dihydrogen peroxide; toluene-4-sulfonic acid; ozone; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; benzene;
DOI:10.1021/ja00343a030

Reference yield:

: 6102-41-6,6102-44-9,14116-78-0,70749-10-9,70749-11-0,78341-47-6
rel-(4aS,8aS)-1,2,3,4,4a,5,8,8a-octahydronaphthalen-2-one

: 80664-53-5
N--5-thiophenoxy-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / lithium aluminum hydride / tetrahydrofuran / 1.) -70 deg C, 75 min, 2.) 3 h

2: 62 percent / triphenylphosphine, diethyl azodicarboxylate / tetrahydrofuran / 1.) 0 deg C, 45 min, 2.) room temperature, 30 min

3: 1.) ozone, 2.) sodium borohydride / methanol / 1.) -78 deg C, 43 min

4: 1.) o-nitrophenyl selenocyanate, tri-n-butylphosphine, 2.) aq. hydrogen peroxide / 1.) THF, 0 deg C, 15 min; room temperature, 45 min, 2.) 0 deg C, 20 min; 30 min

5: 1.) sodium borohydride, hydrochloric acid, pH 3, 2.) p-toluenesulfonic acid / 1.) ethanol, 0 deg C, 4 h, 2.) 30 min

With hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; ortho-nitrophenyl selenocyanate; tributylphosphine; dihydrogen peroxide; toluene-4-sulfonic acid; ozone; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;
DOI:10.1021/ja00343a030

Reference yield:

: 78308-01-7
N-succinimide

: 80664-53-5
N--5-thiophenoxy-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) ozone, 2.) sodium borohydride / methanol / 1.) -78 deg C, 43 min

2: 1.) o-nitrophenyl selenocyanate, tri-n-butylphosphine, 2.) aq. hydrogen peroxide / 1.) THF, 0 deg C, 15 min; room temperature, 45 min, 2.) 0 deg C, 20 min; 30 min

3: 1.) sodium borohydride, hydrochloric acid, pH 3, 2.) p-toluenesulfonic acid / 1.) ethanol, 0 deg C, 4 h, 2.) 30 min

With hydrogenchloride; sodium tetrahydroborate; ortho-nitrophenyl selenocyanate; tributylphosphine; dihydrogen peroxide; toluene-4-sulfonic acid; ozone; In methanol;
DOI:10.1021/ja00343a030