(E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-(6-hydroxyhex-1-enyl)benzamide

Base Information

Chemical Name:(E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-(6-hydroxyhex-1-enyl)benzamide
CAS No.:1253943-70-2
Molecular Formula:C₂₃H₂₃F₃N₂O₃
Molecular Weight:432.442
Hs Code.:

Synonyms:(E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-(6-hydroxyhex-1-enyl)benzamide

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Chemical Property of (E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-(6-hydroxyhex-1-enyl)benzamide

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Technology Process of (E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-(6-hydroxyhex-1-enyl)benzamide

There total 5 articles about (E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-(6-hydroxyhex-1-enyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 199294-05-8
(HO)2BC₂H₂C₄H₈OH

: 1253943-54-2
N-(4-cyano-3-trifluoromethylphenylcarbamoyl)-3-ethoxyphenyl trifluoromethanesulfonate

: 1253943-70-2
(E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-(6-hydroxyhex-1-enyl)benzamide

Guidance literature:: (HO)2BC₂H₂C₄H₈OH; N-(4-cyano-3-trifluoromethylphenylcarbamoyl)-3-ethoxyphenyl trifluoromethanesulfonate; With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 0.25h; Microwave irradiation; Inert atmosphere;

With dihydrogen peroxide; sodium hydroxide; In 1,4-dioxane; water; benzene; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1002/cmdc.201000158

Reference yield:

: 154714-19-9
5-hydroxy-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 1253943-70-2
(E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-(6-hydroxyhex-1-enyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 3 h / Inert atmosphere

2.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; n-butyllithium / tetrahydrofuran; hexane / 0 - 25 °C / Inert atmosphere

2.2: 2 h / 80 °C / Inert atmosphere

3.1: pyridine / 25 °C

4.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 100 °C / Microwave irradiation; Inert atmosphere

4.2: 1 h / 20 °C / Inert atmosphere

With pyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; hexane; acetone; 4.1: Suzuki cross coupling;
DOI:10.1002/cmdc.201000158

Reference yield:

: 1253943-53-1
N-(4-cyano-3-trifluoromethylphenyl)-6-ethoxy-2-hydroxybenzamide

: 1253943-70-2
(E)-N-(4-cyano-3-trifluoromethylphenyl)-2-ethoxy-6-(6-hydroxyhex-1-enyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 25 °C

2.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 100 °C / Microwave irradiation; Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With pyridine; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 2.1: Suzuki cross coupling;
DOI:10.1002/cmdc.201000158