Technology Process of C26H38N2O8
There total 4 articles about C26H38N2O8 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / -15 °C
1.2: 95 percent / NaBH4 / H2O
2.1: 97 percent / imidazole / dimethylformamide
3.1: 97 percent / DMAP / acetonitrile
4.1: 99 percent / TBAF / tetrahydrofuran
5.1: (COCl)2; DMSO; Et3N / CH2Cl2 / -65 °C
6.1: 92 percent / K2CO3; 18-crown-6 / toluene; acetonitrile / -15 °C
With
1H-imidazole; dmap; oxalyl dichloride; 18-crown-6 ether; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl sulfoxide; triethylamine; isobutyl chloroformate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
5.1: Swern oxidation / 6.1: Horner-Emmons olefination;
DOI:10.1021/ol0269852
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 97 percent / DMAP / acetonitrile
2: 99 percent / TBAF / tetrahydrofuran
3: (COCl)2; DMSO; Et3N / CH2Cl2 / -65 °C
4: 92 percent / K2CO3; 18-crown-6 / toluene; acetonitrile / -15 °C
With
dmap; oxalyl dichloride; 18-crown-6 ether; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; dichloromethane; toluene; acetonitrile;
3: Swern oxidation / 4: Horner-Emmons olefination;
DOI:10.1021/ol0269852
- Guidance literature:
-
Multi-step reaction with 2 steps
1: (COCl)2; DMSO; Et3N / CH2Cl2 / -65 °C
2: 92 percent / K2CO3; 18-crown-6 / toluene; acetonitrile / -15 °C
With
oxalyl dichloride; 18-crown-6 ether; potassium carbonate; dimethyl sulfoxide; triethylamine;
In
dichloromethane; toluene; acetonitrile;
1: Swern oxidation / 2: Horner-Emmons olefination;
DOI:10.1021/ol0269852