N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-phenoxyacetamide

Base Information

Chemical Name:N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-phenoxyacetamide
CAS No.:1616074-67-9
Molecular Formula:C₂₀H₂₄N₂O₃
Molecular Weight:340.422
Hs Code.:

Synonyms:N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-phenoxyacetamide

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Chemical Property of N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-phenoxyacetamide

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Technology Process of N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-phenoxyacetamide

There total 3 articles about N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-phenoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 954279-15-3
1-amino-3-(3,4-dihydroisoquinoline-2(1H)-yl)propan-2-ol

: 122-59-8
2-phenoxyacetic acid

: 1616074-67-9
N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-phenoxyacetamide

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 25 ℃; for 16h;

Reference yield:

: 91-21-4
1,2,3,4-tetrahydroisoquinoline

: 1616074-67-9
N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-phenoxyacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetonitrile / 1 h / 0 °C

1.2: 16 h / 22 °C

2.1: ammonia / ethanol / 3 h / -78 - 80 °C / Sealed tube

3.1: triethylamine; HATU / dichloromethane / 16 h / 25 °C

With ammonia; potassium carbonate; triethylamine; HATU; In ethanol; dichloromethane; acetonitrile;

Reference yield:

: 140406-65-1
2-(oxiran-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline

: 1616074-67-9
N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-2-phenoxyacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonia / ethanol / 3 h / -78 - 80 °C / Sealed tube

2: triethylamine; HATU / dichloromethane / 16 h / 25 °C

With ammonia; triethylamine; HATU; In ethanol; dichloromethane;