3-(pyridin-3-yl)-N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)acrylamide

Base Information

Chemical Name:3-(pyridin-3-yl)-N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)acrylamide
CAS No.:1407972-32-0
Molecular Formula:C₂₁H₁₅F₃N₂O₄S
Molecular Weight:448.422
Hs Code.:

Synonyms:3-(pyridin-3-yl)-N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)acrylamide

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Chemical Property of 3-(pyridin-3-yl)-N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)acrylamide

Chemical Property:

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Technology Process of 3-(pyridin-3-yl)-N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)acrylamide

There total 4 articles about 3-(pyridin-3-yl)-N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1407972-35-3
4-[[3-(trifluoromethoxy)benzene]sulfonyl]aniline

: 1126-72-3
3-pyridin-3-yl-acryloyl chloride

: 1407972-32-0
3-(pyridin-3-yl)-N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)acrylamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 2h;

Reference yield:

: 15898-43-8
sodium 4-acetamidobenzenesulfinate

: 1407972-32-0
3-(pyridin-3-yl)-N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper diacetate / 1,4-dioxane; dimethyl sulfoxide / 16 h / 60 °C

2: sodium hydroxide; water / ethanol / 4 h / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C

With water; copper diacetate; potassium carbonate; sodium hydroxide; In 1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1407972-33-1
N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)acetamide

: 1407972-32-0
3-(pyridin-3-yl)-N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / ethanol / 4 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 50 °C

With water; potassium carbonate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;