1126-72-3

Usage

Uses

Used in Pharmaceutical Production:
3-(3-PYRIDINYL)-2PROPENYL CHLORIDE is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Production:
In the agrochemical industry, 3-(3-PYRIDINYL)-2PROPENYL CHLORIDE serves as a crucial component in the creation of pesticides and other crop protection agents. Its reactivity contributes to the production of effective and targeted agrochemicals.
Used in Organic Synthesis:
3-(3-PYRIDINYL)-2PROPENYL CHLORIDE is utilized as a reagent in organic synthesis, particularly for the formation of carbon-carbon bonds. Its versatility in chemical reactions makes it a valuable tool for creating a wide range of organic compounds.
Used in Chemical Research:
As a compound with distinct chemical properties, 3-(3-PYRIDINYL)-2PROPENYL CHLORIDE is employed in research settings to explore new reaction pathways, develop innovative synthetic methods, and understand the underlying mechanisms of various chemical processes.

InChI:InChI=1/C8H6ClNO/c9-8(11)4-3-7-2-1-5-10-6-7/h1-6H/b4-3+

Upstream product

• 19337-97-4 trans-3-(3-pyridyl)acrylic acid 
• 59607-99-7 ethyl (E)-3-(pyridin-3-yl)acrylate 
• 500-22-1 3-pyridinecarboxaldehyde 
• 1126-74-5 3-(pyridin-3-yl)acrylic acid 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 1407972-30-8 N-(4-((4-methoxyphenyl)sulfonyl)phenyl)-3-(pyridin-3-yl)acrylamide 
• 1407972-32-0 3-(pyridin-3-yl)-N-(4-((3-(trifluoromethoxy)phenyl)sulfonyl)phenyl)acrylamide 
• 1246495-00-0 6-{4-[(E)-3-(pyridin-3-yl)acryloylamino]-3-fluorophenyl}-2-ethylamino-N-[2-(piperidin-1-yl)ethyl]nicotinamide 
• 1290541-46-6 3-(phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone 

Relevant academic research and scientific papers

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51

RAD51 is a vital component of the homologous recombination DNA repair pathway and is overexpressed in drug-resistant cancers, including aggressive triple negative breast cancer (TNBC). A proposed strategy for improving therapeutic outcomes for patients is through small molecule inhibition of RAD51, thereby sensitizing tumor cells to DNA damaging irradiation and/or chemotherapy. Here we report structure-activity relationships for a library of quinazolinone derivatives. A novel RAD51 inhibitor (17) displays up to 15-fold enhanced inhibition of cell growth in a panel of TNBC cell lines compared to compound B02, and approximately 2-fold increased inhibition of irradiation-induced RAD51 foci formation. Additionally, compound 17 significantly inhibits TNBC cell sensitivity to DNA damage, implying a potentially targeted therapy for cancer treatment.

Synthesis and evaluation of N-heteroaromatic ring-based analogs of piperlongumine as potent anticancer agents

Piperlongumine (PL) selectively targets a wide spectrum of cancer cells and induces their death by triggering various pathways, including apoptosis, necrosis and autophagy. However, the poor solubility is a serious concern for intensive study and clinical application. We synthesized its analogs 1–9 by replacement of the trimethoxyphenyl of PL with an N-heteroaromatic ring and/or not introduction of 2-Cl. These compounds improved aqueous solubility and displayed potent anticancer activity. The most active compound 9 selectively enhanced ROS levels in colon cancer cells and inhibited the cell proliferation but sparing non-tumor colon cells. Importantly, 9 significantly repressed tumor growth in an HCT-116 xenograft mouse model, suggesting that these N-heteroaromatic ring-based analogs of PL warrant further investigation.

Novel non-trimethoxylphenyl piperlongumine derivatives selectively kill cancer cells

Piperlongumine (PL) is a natural alkaloid with broad biological activities. Twelve analogues have been designed and synthesized with non-substituted benzyl rings or heterocycles in this work. Most of the compounds showed better anticancer activities than the parent PL without apparent toxicity in normal cells. Elevation of cellular ROS levels was one of the main anticancer mechanisms of these compounds. Cell apoptosis and cell cycle arrest for the best compound ZM90 were evaluated and similar mechanism of action with PL was demonstrated. The SAR was also characterized, providing worthy directions for further optimization of PL compounds.

Pyridyl-substituted quinoline derivative as well as preparation method and application thereof

The invention belongs to the field of anti-cancer drugs, and particularly relates to a pyridyl substituted quinoline derivative as well as a preparation method and application thereof. The invention provides a compound shown as a formula I, a stereoisomer or a pharmaceutically acceptable salt thereof. Compared with the existing antitumor drugs, the compound provided by the invention has excellent antitumor activity on A431, SK-BR-3, BT474 and the like, and has a good application prospect. Moreover, the preparation method of the compound is low in cost, simple in step, mild in reaction condition, high in yield and easy for post-treatment.

(E)-3-heteroaromatic propyl-2-enoic acid derivative as well as preparation and application thereof

The invention relates to a (E)-3-heteroaromatic propyl-2-enoic acid derivative, and also relates to a preparation method and pharmaceutical application thereof. The compound is a novel Nrf2 activatorand has the effects of resisting oxidative stress, resisting neuritis and enhancing mitochondrial functions and biogenesis by effectively activating an Nrf2 signal path, so that nerve cells are protected, and the compound can be used for treating neurodegenerative diseases and cerebral apoplexy. In addition, the novel Nrf2 activator can also be used to treat autoimmune diseases, diabetes and nephropathy, and other chronic diseases.

Co(iii)-catalyzed: Z -selective oxidative C-H/C-H cross-coupling of alkenes with triisopropylsilylacetylene

A Co(iii)-catalyzed direct oxidative C-H/C-H cross-coupling reaction of acrylamides with triisopropylsilylacetylene is presented. It is applicable to unsubstituted, internal and terminal acrylamides with a broad functionality tolerance. The feasibility of

Isoalantolactone derivative, pharmaceutical composition and application thereof

The invention relates to an isoalantolactone derivative, a pharmaceutical composition and application thereof, especially use of the isoalantolactone derivative shown as formula (I) or a salt pharmaceutical compound thereof in preparation of adjuvant drugs treating cancer, a pharmaceutical composition containing a therapeutically effective amount of isoalantolactone derivative (I) or its salt anda pharmaceutically acceptable carrier or a composition with other anticancer drugs.

Small molecule inhibitor, preparation method thereof and application of small molecule inhibitor in treatment of multiple myeloma

The invention discloses a small molecule inhibitor, a preparation method thereof and application of the small molecule inhibitor in treatment of multiple myeloma. The small molecule inhibitor has a structural formula shown in a formula I or formula II or formula III or formula IV. The invention also provides the preparation method of the small molecule inhibitor. The small molecule inhibitor can be used for inhibiting the activity of Bruton tyrosine protein kinase, and therefore can be applied to the treatment of the multiple myeloma, such as IgE-type multiple myeloma.

Lewis Acid Enabled Copper-Catalyzed Asymmetric Synthesis of Chiral β-Substituted Amides

Here we report that readily available silyl- and boron-based Lewis acids in combination with chiral copper catalysts are able to overcome the reactivity issues of unactivated enamides, known as the least reactive carboxylic acid derivatives, toward alkyla

SMALL MOLECULE INHIBITORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT)

The present invention relates to novel compounds, their use as anti-cancer agents and their synthesis. In particular, the compounds contain cluster boron moieties such as carborane or a borohydride and act as inhibitors for the enzyme Nampt. The biologica