2-(4-((2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)-phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

Base Information

Chemical Name:2-(4-((2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)-phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole
CAS No.:1401728-56-0
Molecular Formula:C₂₄H₂₈N₆O
Molecular Weight:416.526
Hs Code.:

Synonyms:2-(4-((2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)-phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

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Chemical Property of 2-(4-((2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)-phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

Chemical Property:

Purity/Quality:: 99%, ^*data from raw suppliers

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Technology Process of 2-(4-((2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)-phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

There total 8 articles about 2-(4-((2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)-phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl 4-(5-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate

: 1401728-56-0
2-(4-((2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)-phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

Guidance literature:: tert-butyl 4-(5-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)phenyl)-1,3,4-oxadiazol-2-yl)piperidine-1-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h;

Reference yield:

: 1401728-86-6
4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)benzoic acid

: 1401728-56-0
2-(4-((2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)-phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,4,6-trimethyl-pyridine / N,N-dimethyl-formamide / 0.5 h / 23 °C / Inert atmosphere

1.2: 12 h / 23 °C / Inert atmosphere

2.1: p-toluenesulfonyl chloride; triethylamine / dichloromethane / 12 h / 23 °C

3.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

3.2: 6 h / 20 °C

With 2,4,6-trimethyl-pyridine; triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 187834-88-4
tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate

: 1401728-56-0
2-(4-((2-Ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)-phenyl)-5-(piperidin-4-yl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,4,6-trimethyl-pyridine / N,N-dimethyl-formamide / 0.5 h / 23 °C / Inert atmosphere

1.2: 12 h / 23 °C / Inert atmosphere

2.1: p-toluenesulfonyl chloride; triethylamine / dichloromethane / 12 h / 23 °C

3.1: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

3.2: 6 h / 20 °C

With 2,4,6-trimethyl-pyridine; triethylamine; p-toluenesulfonyl chloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;