tert-butyl 4-(2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)benzoyl)hydrazinecarbonyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)benzoyl)hydrazinecarbonyl)piperidine-1-carboxylate
CAS No.:1401729-06-3
Molecular Formula:C₂₉H₃₈N₆O₄
Molecular Weight:534.659
Hs Code.:

Synonyms:tert-butyl 4-(2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)benzoyl)hydrazinecarbonyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)benzoyl)hydrazinecarbonyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)benzoyl)hydrazinecarbonyl)piperidine-1-carboxylate

There total 11 articles about tert-butyl 4-(2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)benzoyl)hydrazinecarbonyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1401728-88-8
4-(2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-ylmethyl)benzoic acid hydrazide

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1401729-06-3
tert-butyl 4-(2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)benzoyl)hydrazinecarbonyl)piperidine-1-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.6b01703

Reference yield:

: 1401728-86-6
4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)benzoic acid

: 187834-88-4
tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate

: 1401729-06-3
tert-butyl 4-(2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)benzoyl)hydrazinecarbonyl)piperidine-1-carboxylate

Guidance literature:: 4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)benzoic acid; With 2,4,6-trimethyl-pyridine; In N,N-dimethyl-formamide; at 23 ℃; for 0.5h; Inert atmosphere;

tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 23 ℃; for 12h; Inert atmosphere;

Reference yield:

: 33279-01-5
3-oxo-pentanenitrile

: 1401729-06-3
tert-butyl 4-(2-(4-((2-ethyl-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)methyl)benzoyl)hydrazinecarbonyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: L-proline / ethanol / 16 h / 22 °C

2.1: hydrogen; palladium 10% on activated carbon / methanol; acetonitrile / 2 h / 25 °C / 2585.81 Torr

3.1: hydrazine / methanol / 3 h / 65 °C

4.1: acetic acid; hydrogenchloride; water / 43 h / 110 °C

5.1: 2,4,6-trimethyl-pyridine / N,N-dimethyl-formamide / 0.5 h / 23 °C / Inert atmosphere

5.2: 12 h / 23 °C / Inert atmosphere

With 2,4,6-trimethyl-pyridine; hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; acetic acid; L-proline; hydrazine; In methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;