C₁₁H₁₀Cl₂F₃NO₃S

Base Information

• Chemical Name: C₁₁H₁₀Cl₂F₃NO₃S
• CAS No.: 1392848-78-0
• Molecular Formula: C₁₁H₁₀Cl₂F₃NO₃S
• Molecular Weight: 364.173
• Mol file: 1392848-78-0.mol

Synonyms:C₁₁H₁₀Cl₂F₃NO₃S

Chemical Property of C₁₁H₁₀Cl₂F₃NO₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₁₁H₁₀Cl₂F₃NO₃S

There total 3 articles about C₁₁H₁₀Cl₂F₃NO₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-2-amino-5,5,5-trifluoropentanoic acid (122565-29-1,23809-57-6) → C11H10Cl2F3NO3S (1392848-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 13 h / pH 10.3 - 10.7 / Large scale

2: oxalyl dichloride / 2-methyltetrahydrofuran / 0.5 h

With oxalyl dichloride; sodium hydroxide; In 2-methyltetrahydrofuran; water;

DOI:10.1021/op400013e

Reference yield:

5,5,5-trifluoro-2-oxopentanoic acid (118311-18-5) → C11H10Cl2F3NO3S (1392848-78-0)

Guidance literature:

Multi-step reaction with 3 steps

1: D-glucose; NADP; D-AADH and GDH enzyme mixture from E_. coli gdhA^minus cells; sodium hydroxide; ammonium chloride / water / 20 h / 30 °C / pH 9 / Enzymatic reaction

2: sodium hydroxide / water / 13 h / pH 10.3 - 10.7 / Large scale

3: oxalyl dichloride / 2-methyltetrahydrofuran / 0.5 h

With oxalyl dichloride; D-glucose; D-AADH and GDH enzyme mixture from E_. coli gdhA^minus cells; NADP; ammonium chloride; sodium hydroxide; In 2-methyltetrahydrofuran; water;

DOI:10.1021/op400013e

Reference yield:

(R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanoic acid (1392848-77-9) → C11H10Cl2F3NO3S (1392848-78-0)

Guidance literature:

With oxalyl dichloride; In 2-methyltetrahydrofuran; for 0.5h;

DOI:10.1021/op400013e

upstream raw materials:

(2R)-2-amino-5,5,5-trifluoropentanoic acid

5,5,5-trifluoro-2-oxopentanoic acid

(R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanoic acid

Downstream raw materials:

(R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide