(R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanoic acid

Base Information

• Chemical Name: (R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanoic acid
• CAS No.: 1392848-77-9
• Molecular Formula: C₁₁H₁₁ClF₃NO₄S
• Molecular Weight: 345.727
• Mol file: 1392848-77-9.mol

Synonyms:

Chemical Property of (R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanoic acid

There total 2 articles about (R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.9%

(2R)-2-amino-5,5,5-trifluoropentanoic acid (122565-29-1,23809-57-6) + 4-chlorobenzenesulfonyl chloride (98-60-2) → (R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanoic acid (1392848-77-9)

Guidance literature:

With sodium hydroxide; In water; for 13h; pH=10.3 - 10.7; Large scale;

DOI:10.1021/op400013e

Reference yield:

5,5,5-trifluoro-2-oxopentanoic acid (118311-18-5) → (R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanoic acid (1392848-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: D-glucose; NADP; D-AADH and GDH enzyme mixture from E_. coli gdhA^minus cells; sodium hydroxide; ammonium chloride / water / 20 h / 30 °C / pH 9 / Enzymatic reaction

2: sodium hydroxide / water / 13 h / pH 10.3 - 10.7 / Large scale

With D-glucose; D-AADH and GDH enzyme mixture from E_. coli gdhA^minus cells; NADP; ammonium chloride; sodium hydroxide; In water;

DOI:10.1021/op400013e

Reference yield:

(R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanoic acid (1392848-77-9) → C11H10Cl2F3NO3S (1392848-78-0)

Guidance literature:

With oxalyl dichloride; In 2-methyltetrahydrofuran; for 0.5h;

DOI:10.1021/op400013e

upstream raw materials:

(2R)-2-amino-5,5,5-trifluoropentanoic acid

4-chlorobenzenesulfonyl chloride

5,5,5-trifluoro-2-oxopentanoic acid

Downstream raw materials:

C₁₁H₁₀Cl₂F₃NO₃S