2(R)-(3-chloro-4-methylsulfanylphenyl)-N-methyl-N-[1(R)-methyl-2-oxo-2(R)-phenylethyl]-3-(2-oxocyclopentyl)proprionamide

Base Information

Chemical Name:2(R)-(3-chloro-4-methylsulfanylphenyl)-N-methyl-N-[1(R)-methyl-2-oxo-2(R)-phenylethyl]-3-(2-oxocyclopentyl)proprionamide
CAS No.:1393926-51-6
Molecular Formula:C₂₅H₃₀ClNO₃S
Molecular Weight:460.037
Hs Code.:

Synonyms:2(R)-(3-chloro-4-methylsulfanylphenyl)-N-methyl-N-[1(R)-methyl-2-oxo-2(R)-phenylethyl]-3-(2-oxocyclopentyl)proprionamide

Suppliers and Price of 2(R)-(3-chloro-4-methylsulfanylphenyl)-N-methyl-N-[1(R)-methyl-2-oxo-2(R)-phenylethyl]-3-(2-oxocyclopentyl)proprionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2(R)-(3-chloro-4-methylsulfanylphenyl)-N-methyl-N-[1(R)-methyl-2-oxo-2(R)-phenylethyl]-3-(2-oxocyclopentyl)proprionamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2(R)-(3-chloro-4-methylsulfanylphenyl)-N-methyl-N-[1(R)-methyl-2-oxo-2(R)-phenylethyl]-3-(2-oxocyclopentyl)proprionamide

There total 11 articles about 2(R)-(3-chloro-4-methylsulfanylphenyl)-N-methyl-N-[1(R)-methyl-2-oxo-2(R)-phenylethyl]-3-(2-oxocyclopentyl)proprionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.5%

: 625113-43-1
2(R)-(3-chloro-4-methylsulfanyl-phenyl)-3-(2-hydroxycyclopentyl)-N-[2(R)-hydroxy-1(R)-methyl-2(R)-phenylethyl]-N-methyl-proprionamide

: 1393926-51-6
2(R)-(3-chloro-4-methylsulfanylphenyl)-N-methyl-N-[1(R)-methyl-2-oxo-2(R)-phenylethyl]-3-(2-oxocyclopentyl)proprionamide

Guidance literature:: With tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide; In dichloromethane; at 25 ℃; for 0.333333h; diastereoselective reaction; Molecular sieve; Inert atmosphere;
DOI:10.1021/jm3008689

Reference yield:

: 17733-22-1
2-chlorothioanisole

: 1393926-51-6
2(R)-(3-chloro-4-methylsulfanylphenyl)-N-methyl-N-[1(R)-methyl-2-oxo-2(R)-phenylethyl]-3-(2-oxocyclopentyl)proprionamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: aluminum (III) chloride / chloroform / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / toluene / 1.5 h / 50 - 60 °C / Inert atmosphere

3.1: hydrazine hydrate; potassium hydroxide / 16 h / -50 - 100 °C / Inert atmosphere

4.1: potassium carbonate; pivaloyl chloride / acetone / 0.33 h / -10 - 20 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane; n-butyllithium / hexane; tetrahydrofuran / 1 h / -45 - 0 °C / Inert atmosphere

5.2: 3 h / -45 - 0 °C / Inert atmosphere

6.1: pyridinium p-toluenesulfonate / ethanol / 2 h / 50 °C / Inert atmosphere

7.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 0.33 h / 25 °C / Molecular sieve; Inert atmosphere

With aluminum (III) chloride; n-butyllithium; tetrapropylammonium perruthennate; water; pyridinium p-toluenesulfonate; pivaloyl chloride; potassium carbonate; hydrazine hydrate; 4-methylmorpholine N-oxide; potassium hydroxide; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane; dichloromethane; chloroform; acetone; toluene;
DOI:10.1021/jm3008689

Reference yield:

: 58393-19-4
2-(tetrahydro-pyran-2-yloxy)-cyclopentanecarboxylic acid ethyl ester

: 1393926-51-6
2(R)-(3-chloro-4-methylsulfanylphenyl)-N-methyl-N-[1(R)-methyl-2-oxo-2(R)-phenylethyl]-3-(2-oxocyclopentyl)proprionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 0 - 25 °C / Inert atmosphere

2.1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 3 h / 0 - 25 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane; n-butyllithium / hexane; tetrahydrofuran / 1 h / -45 - 0 °C / Inert atmosphere

3.2: 3 h / -45 - 0 °C / Inert atmosphere

4.1: pyridinium p-toluenesulfonate / ethanol / 2 h / 50 °C / Inert atmosphere

5.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 0.33 h / 25 °C / Molecular sieve; Inert atmosphere

With 1H-imidazole; lithium aluminium tetrahydride; n-butyllithium; tetrapropylammonium perruthennate; iodine; pyridinium p-toluenesulfonate; 4-methylmorpholine N-oxide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1021/jm3008689